Abstract
Research has been lately prospering in the field of Janus nanoparticles, focusing on new synthesis techniques and their application in various fields. This is due to the unique characteristics possessed by this type of particles such as their anisotropic nature, and their synergistic potential for combination therapy in addition to the multilevel targeting. These unique features are essential in several biomedical applications, especially the controlled drug delivery. Various techniques have been used for the synthesis of Janus nanoparticles including; masking, self-assembly, microfluidic and phase separation. They are all aiming at production of uniformly sized Janus particles with spatially separated functionalities. Herein, the main synthesis approaches of various Janus nanoparticles are briefly reviewed with the provision of examples of studies focusing on the potential applications of Janus particles in controlled drug delivery.
Keywords: Janus, nanoparticles, nanocapsules, nanomotors, microfluidic, drug delivery.
Current Pharmaceutical Biotechnology
Title:Janus Nano- and Microparticles as Smart Drug Delivery Systems
Volume: 17 Issue: 8
Author(s): Ibrahim M. El-Sherbiny and Yasmine Abbas
Affiliation:
Keywords: Janus, nanoparticles, nanocapsules, nanomotors, microfluidic, drug delivery.
Abstract: Research has been lately prospering in the field of Janus nanoparticles, focusing on new synthesis techniques and their application in various fields. This is due to the unique characteristics possessed by this type of particles such as their anisotropic nature, and their synergistic potential for combination therapy in addition to the multilevel targeting. These unique features are essential in several biomedical applications, especially the controlled drug delivery. Various techniques have been used for the synthesis of Janus nanoparticles including; masking, self-assembly, microfluidic and phase separation. They are all aiming at production of uniformly sized Janus particles with spatially separated functionalities. Herein, the main synthesis approaches of various Janus nanoparticles are briefly reviewed with the provision of examples of studies focusing on the potential applications of Janus particles in controlled drug delivery.
Export Options
About this article
Cite this article as:
El-Sherbiny M. Ibrahim and Abbas Yasmine, Janus Nano- and Microparticles as Smart Drug Delivery Systems, Current Pharmaceutical Biotechnology 2016; 17 (8) . https://dx.doi.org/10.2174/1389201017666160401145438
DOI https://dx.doi.org/10.2174/1389201017666160401145438 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Involvement of the Transforming Growth Factor β in the Pathogenesis of Hereditary Hemorrhagic Telangiectasia
Current Pharmaceutical Design Protein Kinases as Drug Targets in Cancer
Current Cancer Drug Targets Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery Effect of Polyphenolic Compounds from Solanum torvum on Plasma Lipid Peroxidation, Superoxide anion and Cytochrome P450 2E1 in Human Liver Microsomes
Medicinal Chemistry MicroRNA-21: From Cancer to Cardiovascular Disease
Current Drug Targets Multifunctional Hydroxyapatite-based Nanoparticles for Biomedicine: Recent Progress in Drug Delivery and Local Controlled Release
Current Mechanics and Advanced Materials Development and In Vitro Proof-of-Concept of Interstitially Targeted Zinc- Phthalocyanine Liposomes for Photodynamic Therapy
Current Medicinal Chemistry Editorial (Thematic Issue: The Role of Reactive Oxygen Species in Organ Pathologies Due to Drugs Abuse: Do We Have the Culprit?)
Mini-Reviews in Organic Chemistry In-Vitro Anticancer Evaluation and Docking Study of Novel Benzo[g] Quinazoline-sulfonamide Derivatives
Medicinal Chemistry Zinc and its Specific Transporters as Potential Targets in Airway Disease
Current Drug Targets Anti-Inflammatory Drugs and Prediction of New Structures by Comparative Analysis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Nutritional Antioxidants and Adaptive Cell Responses: An Update
Current Molecular Medicine Recent Mass Spectrometric Based Methods in Quantitative N-linked Glycoproteomics
Current Proteomics Angiogenesis Inhibitors and Vascular Disrupting Agents in Non-Small Cell Lung Cancer
Current Medicinal Chemistry Retinoids as Differentiating Agents in Oncology: A Network of Interactions with Intracellular Pathways as the Basis for Rational Therapeutic Combinations
Current Pharmaceutical Design Will Antiangiogenic Agents be a Future for Mesothelioma Therapy?
Current Medicinal Chemistry The Role of Endogenous H2S in Cardiovascular Physiology
Current Pharmaceutical Biotechnology Intramolecular Cyclisation of β-Aryl-β-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity
Current Medicinal Chemistry Synthesis, Characterization, and Molecular Structure of a Novel Zinc (II) Complex: Assessment of Impact of MDR1Pgp Expression on its Cytotoxic Activity
Medicinal Chemistry 18F-FDG PET/CT in Restaging and Evaluation of Response to Therapy in Lung Cancer: State of the Art
Current Radiopharmaceuticals