Abstract
Cervical remodeling (CR) is a complex process, which, in part, is believed to be induced by physiological inflammation. Even though the female reproductive tissues are richly innervated by nerves from the parasympathetic pelvic autonomic ganglia, sensory dorsal root and nodose ganglia, their roles (neuronal factors) in this process (CR) has been largely attributed to sex steroid hormones, until recently. Here, we discuss the interaction between neuropeptides derived from peripheral nerves associated with uterine cervix and estrogen, and their likely impact on cervical remodeling. It is likely that these neuronal factors, under the influence of estrogen, could induce physiological inflammation during cervical remodeling by promoting the expression of vascular endothelial growth factor, among other factors.
Keywords: Cervix, cervical remodeling, innervation, neuropeptides, vascular endothelial growth factor (VEGF).
Graphical Abstract
Call for Papers in Thematic Issues
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The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
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The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
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