Abstract
Nitric Oxide, synthesized from L-arginine by the nitric oxide synthases, has a complex role within the human body. It contributes to almost every physiological system and has been found to be both protective and toxic in disease states. An aging population faces an increasing incidence of neurodegenerative disease and the pathological action of nitric oxide in Alzheimer’s and Parkinson’s diseases may be important therapeutic targets for the future. Nitric oxide’s protective effects are also important to consider, through inhibition of caspase-3, nitrosylation of NMDA and increased activation of protein kinase B and CREB transcription factor. Nitric oxide has been shown to play a part in long term potentiation, revealing its importance in synaptic plasticity. Due to nitric oxide’s mixed effects it is an exciting and varied therapeutic target. Currently, the impact of these therapies has been explored and developed in animal studies, but is yet to be fully realized in human trials. This paper outlines both the pathological and protective roles of nitric oxide in the central nervous system and the potential pharmacological therapies and targets these indicate.
Keywords: Nitric oxide, neurodegenerative, neuroprotective, Alzheimer’s disease, Parkinson’s disease.
Current Medicinal Chemistry
Title:Is Nitric Oxide Assuming a Janus-Face in The Central Nervous System?
Volume: 23 Issue: 16
Author(s): Felicity Ockelford, Louis Saada, Ehud Gazit and Achala de Mel
Affiliation:
Keywords: Nitric oxide, neurodegenerative, neuroprotective, Alzheimer’s disease, Parkinson’s disease.
Abstract: Nitric Oxide, synthesized from L-arginine by the nitric oxide synthases, has a complex role within the human body. It contributes to almost every physiological system and has been found to be both protective and toxic in disease states. An aging population faces an increasing incidence of neurodegenerative disease and the pathological action of nitric oxide in Alzheimer’s and Parkinson’s diseases may be important therapeutic targets for the future. Nitric oxide’s protective effects are also important to consider, through inhibition of caspase-3, nitrosylation of NMDA and increased activation of protein kinase B and CREB transcription factor. Nitric oxide has been shown to play a part in long term potentiation, revealing its importance in synaptic plasticity. Due to nitric oxide’s mixed effects it is an exciting and varied therapeutic target. Currently, the impact of these therapies has been explored and developed in animal studies, but is yet to be fully realized in human trials. This paper outlines both the pathological and protective roles of nitric oxide in the central nervous system and the potential pharmacological therapies and targets these indicate.
Export Options
About this article
Cite this article as:
Ockelford Felicity, Saada Louis, Gazit Ehud and Mel de Achala, Is Nitric Oxide Assuming a Janus-Face in The Central Nervous System?, Current Medicinal Chemistry 2016; 23 (16) . https://dx.doi.org/10.2174/0929867323666160316124137
DOI https://dx.doi.org/10.2174/0929867323666160316124137 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Development and Validation of a UPLC-MS/MS Method for the Simultaneous
Determination of Verapamil and Trandolapril in Rat Plasma: Application
to a Pharmacokinetic Study
Current Pharmaceutical Analysis Familial Hypercholesterolemia: Etiology, Diagnosis and New Treatment Options
Current Pharmaceutical Design Anti-Endotoxin Agents. 3. Rapid Identification of High-Affinity Lipopolysaccharide-Binding Compounds in a Substituted Polyamine Library
Combinatorial Chemistry & High Throughput Screening Vascular Risk Factors and Neurodegeneration in Ageing Related Dementias: Alzheimer’s Disease and Vascular Dementia
Current Alzheimer Research Bcl-2 Proteins: Targets and Tools for Chemosensitisation of Tumor Cells
Current Medicinal Chemistry - Anti-Cancer Agents QT Prolongation and Anticancer Drugs: Is it a Cardiologist’s Worry? The Oncologist’s Point of View
Reviews on Recent Clinical Trials Class IV Antiarrhythmic Agents: New Compounds Using an Old Strategy
Current Pharmaceutical Design Pharmacological and Biological Activities of Benzazepines: An Overview
Current Bioactive Compounds Patents of Pentoxifylline Administration on Some Diseases and Chronic Wounds
Recent Patents on Regenerative Medicine The Application of Chitosan and Its Derivatives as Nanosized Carriers for the Delivery of Chemical Drugs and Genes or Proteins
Current Drug Targets Treatment of Hypertensive Complications in Pregnancy
Current Pharmaceutical Design Role of Vascular Nitric Oxide in Experimental Liver Cirrhosis
Current Vascular Pharmacology Synthesis, Cytotoxicity and Molecular Docking Simulation of Novel bis-1,4-Dihydropyridines Linked to Aliphatic or Arene Core via Amide or Ester-Amide Linkages
Mini-Reviews in Medicinal Chemistry 5'-Nucleotidases, Nucleosides and their Distribution in the Brain: Pathological and Therapeutic Implications
Current Medicinal Chemistry Established and In-trial GPCR Families in Clinical Trials: A Review for Target Selection
Current Drug Targets Protective Effects of Phenylpropanoids and Phenylpropanoid-rich Essential Oils on the Cardiovascular System
Mini-Reviews in Medicinal Chemistry Neurologic Sequelae in Critical Illness: Evaluation and Outcomes
Current Respiratory Medicine Reviews The Possible Therapeutic Actions of Peroxisome Proliferator-Activated Receptor α(PPARα) Agonists,PPARγ Agonists,3-Hydroxy-3- Methylglutaryl Coenzyme A (HMG-CoA)Reductase Inhibitors,Angiotensin Converting Enzyme (ACE)Inhibitors and Calcium (Ca)-Antagonists on Vascular Endothelial Cells
Current Drug Targets - Cardiovascular & Hematological Disorders Fibromyalgia: The Prototypical Central Sensitivity Syndrome
Current Rheumatology Reviews Revision on Renal Sympathetic Ablation in the Treatment of Resistant Hypertension
Current Hypertension Reviews