ISSN (Print): 2468-1873
ISSN (Online): 2468-1881
Volume 11, 4 Issues, 2021
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ISSN (Print): 2468-1873
ISSN (Online): 2468-1881
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Nanopharmaceutics for Patient Care
Guest Editor(s): Yoshiaki Machida, Yoshinori Kato
The writing experience for Bentham Science Publishers was a pleasant and productive work. In particular for the good organization of the editorial board and the helpfulness of the editor and the reviewers to improve the final manuscript. I am pleased having worked with them.
(Center for NanotechnologyInnovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro 12,I-56127 Pisa, Italy, Italy)
Has contributed: Smart Delivery and Controlled Drug Release with Gold Nanoparticles: New Frontiers in Nanomedicine
As of 21st century, cancer is arguably the most complex and challenging disease known to mankind and
an inevitable public health concern of this millennium [1, 2]. Presently, it is the second major cause for
death worldwide and it was estimated 8.8 million deaths were reported in 2015[1, 3]. Different treatment
strategies such as surgery, radiation, chemo and hormonal therapy are used for cancer treatment, whereas
chemotherapy is found to be common [1, 4]. We are very much aware that the success of cancer therapy
entirely depends on the early detection and effective therapies modulaties including chemotherapy.
Chemotherapy, one of the main therapeutic modality often suffered with limited success due to off targeting
and non-preferential drug distribution, poor penetration to the solid tumor, poor solubility of hydrophobic
cancer drugs, elimination by reticulo-endothelial system (RES) and multidrug resistance (MDR)
[5-9]. Limitation of conventional chemotherapy prompted a new class of nanoformulations (termed as nanomedicine).
Research and therapy in cancer nanotechnology area is developing fast. New insights and
progress in delivery approaches allows for more precise diagnosis, efficacious treatment and quality care.
Newer ideas such as utilizing combination therapy, multifunctional nanoparticles and theranostics in cancer
nanomedicines have greatly evolved over recent years [5, 6-20]. This is evinced that sizeable accomplishment
has been made in this area however toxicity, poorly reproducible chemistry, scale-up and the
cost remain as constraints in cancer nanotechnology that persuade the development of safe biomaterials
based nanoparticles. Through this thematic issue we brought the understanding and perspective altogether
of the expert researchers of cancer nanomedicines, biomedical science, chemistry and formulation from
which we identify future research needed to overcome the limitations associated with the cancer nanomedicines
and facilitate the clinical realization.
Nanotechnology has been applied in the area of medicine to develop nanoparticulate delivery systems.
This delivery system is very promising in the treatment and diagnosis of cancer owing to its entry into the
tissue at molecular level. These delivery systems also overcome the side effects associated with conventional
therapies. The nanoparticles exert tumour specific targeting and delivery by enhancing the permeability
and retention effect, avoids the reticoendothelial system. The nanoparticulate drug delivery systems
also offer feasibility of incorporation of both hydrophilic and hydrophobic drug(s), high stability and carrier
capacity and feasibility of various routes of administration.
Singh et al., in “Inhalable nanostructures for lung cancer treatment: progress and challenges” reported
that nanostructure based inhalation chemotherapy is more successful targeting system and also offers reduced
side effects than conventional chemotherapy. Authors highlighted the critical issues, strategies for delivery
and inhalable nanostructures for anticancer drug delivery. Vohra et al., in “Current trends in phytocancer
therapy using nanoparticles” pointed out that herbal medicines have attracted the scientist due to low
toxicity and high efficacy associated with them. This review summarized the recent studies conducted on
herbal nanoparticles and current trends followed by phyto-cancer therapy for cancer treatment. Nithya et al.,
in “Development and In Vitro Characterization of Paclitaxel Loaded Solid Lipid Nanoparticles” developed
nanoparticles of paclitaxel (PTX) (PSLN) were by hot homogenization method using Cutina HR and Gelucire
44/14 as lipid carriers and Solutol HS 15 as a surfactant. The in vitro release studies showed a sustained
release profile for PSLN over a period of 48 hours. SLNs loaded with PTX were found to be more toxic in
killing MCF7 cells at a lower concentration than the free PTX. Gupta et al., in “Formulation and characterization
of gefitinib-loaded polymeric nanoparticles using box-behnken design” developed gefitinib loaded
chitosan nanoparticles (GF-NP) by ionic gelation method using 3-factor 3- level box-behnken design. Seventeen
formulations of the polymeric nanoparticles were prepared using various concentrations of chitosan
(0.1-0.3% w/v), NaTPP (0.2-0.6% w/v) and different volumes of NaTPP (8-12 ml) by ionic gelation method
using trehalose (5% w/v) as cryoprotectant. The nanoparticle formulation with desired characteristics can be
prepared at low concentration of chitosan, optimum concentration ratio of chitosan: NaTPP along with low
volume of NaTPP. Lather et al., in “Polymeric Micelles of Modified Chitosan Block Copolymer as Nanocarrier
for Delivery of Paclitaxel” prepared and characterized the novel polymeric micelles derived from self
assembly of amphiphilic chitosan-bile salt derivative (CS-mPEG-DA) as nanocarrier and evaluated the delivery
of paclitaxel. The polymeric micellar systems derived from copolymerization of chitosan exhibit a
great potential in successful delivery of poorly water soluble or low bioavailable drug - paclitaxel. Dhiman
and Bhalla in “Development and evaluation of lycopene loaded chitosan nanoparticles” investigated the influence
of some precarious variables like, concentration of chitosan, concentration of sodium tripolyphosphate
(STPP) and stirring time on physico-chemical characteristics of lycopene loaded chitosan nanoparticles.
Lycopene loaded chitosan nanoaprticles containing 150 mg of chitosan, 75 mg of sodium TPP, 20 mg
of drug lycopene and with 15 minutes of stirring time showed highest entrapment efficiency of 89.4%.
These nanoparticles showed the great promise for the development of drug delivery system by enhancing the
cellular accumulation of lycopene with chitosan.
I owe appreciations and sincere gratitude and to all who kindly contributed, peer-reviewed the manuscripts
for this special issue in order to sustain the high quality of this journal. I sincerely acknowledge the
editorial board’s productive and appropriate reviews and the entire endeavor in publishing the special issue.
My special thanks are also due to Ms. Syeda Aqsa Jabeen for hard work and efforts for possible publication
of this special issue. I hope that all the readers will be benefitted from this issue.
The importance of nanoparticles has been extensively investigated almost in all the disciplines of science
for variety of applications, especially in drug delivery, biomedical applications and many more. In
this regard, metallic nanoparticles have attracted special attention to the researchers for exploring the multifunctional
applications in biomedical research. These exhibit magnetic, optical and thermal properties of
metallic nanoparticles dependent on size and shape, thus highly useful for applications beyond drug delivery
in other fields like bioengineering, biological labeling, sensor technology, optical devices, chemical
catalysis and cancers. Some of the key metallic elements explored for the production of metallic nanoparticles
include silver, gold, copper, iron oxide, zinc oxide, etc. Several research reports and patents have
been published in the vast research poured in the field of nanoparticles for exploring their multifaceted
applications. The present special issue, in this context, aims to provide an updated account on the patents
reported so far on synthesis, characterization and diverse applications of metallic nanoparticles. This present
guest issue is aimed be highly beneficial for the pharmaceutical and biomedical scientists to keep
abreast of the current advancements in the metallic nanoparticles for drug delivery and biomedical applications.
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