Abstract
Due to eutrophication processes in our water bodies, cyanobacterial blooms can develop worldwide. Most of these blooms are toxic. The most prominent cyanobacterial toxins are the group of the microcystins, which are cyclic heptapeptides, currently with more than 100 congeners known. The biotransformation of microcystins starts with the conjugation to the cell internal tripeptide glutathione, catalysed by glutathione S-transferase enzymes. This conjugate is further broken down to a cysteine conjugate, enhancing the cell internal transport and excretion of the conjugated toxin from the organisms. Still many questions remain open, thinking on an obviously good working detoxification system on the one side and the often seen negative effects up to the death of humans on the other sides.
Keywords: Biotransformation, Metabolism, Microcystins, Phase I and Phase II.
Mini-Reviews in Medicinal Chemistry
Title:Biotransformation of Microcystins in Eukaryotic Cells - Possible Future Research Directions
Volume: 16 Issue: 13
Author(s): Stephan Pflugmacher
Affiliation:
Keywords: Biotransformation, Metabolism, Microcystins, Phase I and Phase II.
Abstract: Due to eutrophication processes in our water bodies, cyanobacterial blooms can develop worldwide. Most of these blooms are toxic. The most prominent cyanobacterial toxins are the group of the microcystins, which are cyclic heptapeptides, currently with more than 100 congeners known. The biotransformation of microcystins starts with the conjugation to the cell internal tripeptide glutathione, catalysed by glutathione S-transferase enzymes. This conjugate is further broken down to a cysteine conjugate, enhancing the cell internal transport and excretion of the conjugated toxin from the organisms. Still many questions remain open, thinking on an obviously good working detoxification system on the one side and the often seen negative effects up to the death of humans on the other sides.
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Cite this article as:
Pflugmacher Stephan, Biotransformation of Microcystins in Eukaryotic Cells - Possible Future Research Directions, Mini-Reviews in Medicinal Chemistry 2016; 16 (13) . https://dx.doi.org/10.2174/1389557516666160219130837
DOI https://dx.doi.org/10.2174/1389557516666160219130837 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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