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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Multimodal Nanomedicine Strategies for Targeting Cancer Cells as well as Cancer Stem Cell Signalling Mechanisms

Author(s): Jagat R. Kanwar*, Rasika M. Samarasinghe, Sishir K. Kamalapuram and Rupinder K. Kanwar

Volume 17, Issue 18, 2017

Page: [1688 - 1695] Pages: 8

DOI: 10.2174/1389557516666160219121634

Price: $65

Abstract

Increasing evidence suggests that stem cells, a small population of cells with unique selfrenewable and tumour regenerative capacity, are aiding tumour re-growth and multidrug resistance. Conventional therapies are highly ineffective at eliminating these cells leading to relapse of disease and formation of chemoresistance tumours. Cancer and stem cells targeted therapies that utilizes nanotherapeutics to delivery anti-cancer drugs to specific sites are continuously investigated. This review focuses on recent research using nanomedicine and targeting entities to eliminate cancer cells and cancer stem cells. Current nanotherapeutics in clinical trials along with more recent publications on targeted therapies are addressed.

Keywords: Aptamers, cancer, chemotherapeutics, stem cells, nanotherapeutics, nanomedicine.

Graphical Abstract

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