Abstract
Alkyl disulfamic acid-functionalized silica-coated magnetic nanoparticles (ADSA-MNPs) have been synthesized as a hybrid organic- inorganic acidic nanoparticles and its catalytic activity has been evaluated in the synthesis of mono-, bis- and tris 1,2-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine via a one-pot three, pseudo-five or pseudo-seven component condensation reaction of aromatic aldehydes, malononitrile and 2-aminobezimidazole under solvent-free heating. The heterogeneous catalyst was facilely separated from the reaction mixture by utilizing external magnetic field and reused for several times without considerable decrease of catalytic performance.
Keywords: Nanoparticles, magnetite, heterogeneous catalysis, sulfamic acid, imidazo[1, 2-a]pyrimidine, multicomponent reaction.
Current Organic Chemistry
Title:Mild Synthesis of mono-, bis- and tris 1,2-Dihydrobenzo[4,5]imidazo[1,2- a]pyrimidine Derivatives Using Alkyl Disulfamic Acid Functionalized Magnetic Nanoparticles
Volume: 20 Issue: 15
Author(s): Mohammad A. Bodaghifard, Zahra Faraki and Ali R. Karimi
Affiliation:
Keywords: Nanoparticles, magnetite, heterogeneous catalysis, sulfamic acid, imidazo[1, 2-a]pyrimidine, multicomponent reaction.
Abstract: Alkyl disulfamic acid-functionalized silica-coated magnetic nanoparticles (ADSA-MNPs) have been synthesized as a hybrid organic- inorganic acidic nanoparticles and its catalytic activity has been evaluated in the synthesis of mono-, bis- and tris 1,2-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine via a one-pot three, pseudo-five or pseudo-seven component condensation reaction of aromatic aldehydes, malononitrile and 2-aminobezimidazole under solvent-free heating. The heterogeneous catalyst was facilely separated from the reaction mixture by utilizing external magnetic field and reused for several times without considerable decrease of catalytic performance.
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Cite this article as:
A. Bodaghifard Mohammad, Faraki Zahra and R. Karimi Ali, Mild Synthesis of mono-, bis- and tris 1,2-Dihydrobenzo[4,5]imidazo[1,2- a]pyrimidine Derivatives Using Alkyl Disulfamic Acid Functionalized Magnetic Nanoparticles, Current Organic Chemistry 2016; 20 (15) . https://dx.doi.org/10.2174/1385272820666160218233729
DOI https://dx.doi.org/10.2174/1385272820666160218233729 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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