Abstract
Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor’s role in the adapted immunity and inflammation as well as the receptor’s expression and function in the CNS with the focus on astrocytes. We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system. These steps will help to elucidate a possible role for this pathway in the physiology of the central and peripheral nervous system and its possible link to human disease.
Keywords: Astrocytes, autoimmunity, central nervous system, EBI2, immune system, neurodegeneration, oligodendrocytes.
Current Drug Targets
Title:The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems
Volume: 17 Issue: 16
Author(s): Aleksandra Rutkowska, Kumlesh K. Dev and Andreas W. Sailer
Affiliation:
Keywords: Astrocytes, autoimmunity, central nervous system, EBI2, immune system, neurodegeneration, oligodendrocytes.
Abstract: Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor’s role in the adapted immunity and inflammation as well as the receptor’s expression and function in the CNS with the focus on astrocytes. We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system. These steps will help to elucidate a possible role for this pathway in the physiology of the central and peripheral nervous system and its possible link to human disease.
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Cite this article as:
Rutkowska Aleksandra, Dev K. Kumlesh and Sailer W. Andreas, The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems, Current Drug Targets 2016; 17 (16) . https://dx.doi.org/10.2174/1389450117666160217123042
DOI https://dx.doi.org/10.2174/1389450117666160217123042 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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