Abstract
Chitosan nanogels present a very interesting combination of valuable characteristics for drug delivery; those derived from their nanometric size, such as, large surface area, rapid stimuli-response, and easy functionalization; and those emerged especially from their biocompatibility, biodegradability and mucoadhesive nature. Due to this, chitosan nanogels have reached a prominent position as nanocarriers and have originated accelerated research worldwide. Diverse methods to prepare chitosan nanogels have been reported, showing a dependence on final swelling, drug encapsulation capability and release properties with different synthesis variables, in such a way that they can be exploited to be modulated. The present review describes the properties of chitosan nanogels, along with the different methods of crosslinking and confining chitosan in nanosized particles, and the various fields of drug delivery where they have been applied. This work aims to emphasize the connection between the characteristics of chitosan and the synthetic variables with the final properties of chitosan nanogels in order to enhance controlled drug loading and a sustained release.
Keywords: Chitosan, nanogels, covalent crosslinking, ionic crosslinking, drug delivery, swelling.
Current Pharmaceutical Design
Title:Covalently and Ionically Crosslinked Chitosan Nanogels for Drug Delivery
Volume: 22 Issue: 22
Author(s): Leyre Pérez-Álvarez, José Manuel Laza and Arturo Álvarez-Bautista
Affiliation:
Keywords: Chitosan, nanogels, covalent crosslinking, ionic crosslinking, drug delivery, swelling.
Abstract: Chitosan nanogels present a very interesting combination of valuable characteristics for drug delivery; those derived from their nanometric size, such as, large surface area, rapid stimuli-response, and easy functionalization; and those emerged especially from their biocompatibility, biodegradability and mucoadhesive nature. Due to this, chitosan nanogels have reached a prominent position as nanocarriers and have originated accelerated research worldwide. Diverse methods to prepare chitosan nanogels have been reported, showing a dependence on final swelling, drug encapsulation capability and release properties with different synthesis variables, in such a way that they can be exploited to be modulated. The present review describes the properties of chitosan nanogels, along with the different methods of crosslinking and confining chitosan in nanosized particles, and the various fields of drug delivery where they have been applied. This work aims to emphasize the connection between the characteristics of chitosan and the synthetic variables with the final properties of chitosan nanogels in order to enhance controlled drug loading and a sustained release.
Export Options
About this article
Cite this article as:
Pérez-Álvarez Leyre, Manuel Laza José and Álvarez-Bautista Arturo, Covalently and Ionically Crosslinked Chitosan Nanogels for Drug Delivery, Current Pharmaceutical Design 2016; 22 (22) . https://dx.doi.org/10.2174/1381612822666160216152008
DOI https://dx.doi.org/10.2174/1381612822666160216152008 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Targeting Striatal Metabotropic Glutamate Receptor Type 5 in Parkinson’s Disease: Bridging Molecular Studies and Clinical Trials
CNS & Neurological Disorders - Drug Targets Oxidized Galectin-1 is an Essential Factor for Peripheral Nerve Regeneration
Current Drug Targets Meet Our Editorial Board Member
Current Pharmaceutical Biotechnology Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role in the Modulation of Pain Response in the Central Nervous System
Current Neuropharmacology New Challenges in CNS Repair: The Immune and Nervous Connection
Current Immunology Reviews (Discontinued) Clinical Implication of Meissner’s Corpuscles
CNS & Neurological Disorders - Drug Targets Editorial (Thematic Issue: Novel Insights into the Role of Anesthetics and Opioids in Organ or Tissue Protection)
Current Pharmaceutical Design Rational Basis for the Use of Bergamot Essential Oil in Complementary Medicine to Treat Chronic Pain
Mini-Reviews in Medicinal Chemistry Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review
Mini-Reviews in Medicinal Chemistry Neurovascular Matrix Metalloproteinases and the Blood-Brain Barrier
Current Pharmaceutical Design Voltage-Gated Sodium Channel Blockers as Immunomodulators
Recent Patents on CNS Drug Discovery (Discontinued) Heme Oxygenase-1 as a Target for the Design of Gene and Pharmaceutical Therapies for Autoimmune Diseases
Current Gene Therapy Minocycline Increases in-vitro Cortical Neuronal Cell Survival after Laser Induced Axotomy
Current Clinical Pharmacology Melatonin, Autophagy and Intestinal Bowel Disease
Current Pharmaceutical Design Glycosphingolipid Structure and Function in Membranes
Current Organic Chemistry From Rapid to Delayed and Remote Postconditioning: The Evolving Concept of Ischemic Postconditioning in Brain Ischemia
Current Drug Targets Editorial [Hot Topic: Why Apoptosis in Pediatric Disorders?]
Current Pediatric Reviews Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury
Mini-Reviews in Medicinal Chemistry The Na+/Ca2+ Exchanger Mediates the Effects of Oxidative Stress in Hypertension
Current Hypertension Reviews Dissecting the Therapeutic Relevance of Gene Therapy in NeuroAIDS: An Evolving Epidemic
Current Gene Therapy