Abstract
In this review we discuss drug design strategies directed to the development of potential anti-influenza A(H1N1) inhibitors of M2 ion channel, neuraminidase (NA), hemagglutinin (HA) and RNA-dependent RNA-polymerase complex (RdRp) major targets, following temporal chronology of their findings. Besides searching for new chemotypes, eventually active against new targets of influenza A (H1N1), the design of optimized analogues of proven drugs is largely pursued, taking into account the emerging insight into the mechanisms of resistance to existing antivirals. Computational studies are also summarized, in order to highlight the structural requirements for further chemical optimizations.
Keywords: Influenza A(H1N1) virus, drug design, M2 ion channel blockers, HA inhibitors, NA inhibitors, RNA polymerse complex inhibitors.
Current Medicinal Chemistry
Title:Fight Against H1N1 Influenza A Virus: Recent Insights Towards the Development of Druggable Compounds
Volume: 23 Issue: 18
Author(s): Michele Tonelli and Elena Cichero
Affiliation:
Keywords: Influenza A(H1N1) virus, drug design, M2 ion channel blockers, HA inhibitors, NA inhibitors, RNA polymerse complex inhibitors.
Abstract: In this review we discuss drug design strategies directed to the development of potential anti-influenza A(H1N1) inhibitors of M2 ion channel, neuraminidase (NA), hemagglutinin (HA) and RNA-dependent RNA-polymerase complex (RdRp) major targets, following temporal chronology of their findings. Besides searching for new chemotypes, eventually active against new targets of influenza A (H1N1), the design of optimized analogues of proven drugs is largely pursued, taking into account the emerging insight into the mechanisms of resistance to existing antivirals. Computational studies are also summarized, in order to highlight the structural requirements for further chemical optimizations.
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Cite this article as:
Tonelli Michele and Cichero Elena, Fight Against H1N1 Influenza A Virus: Recent Insights Towards the Development of Druggable Compounds, Current Medicinal Chemistry 2016; 23 (18) . https://dx.doi.org/10.2174/0929867323666160210124930
DOI https://dx.doi.org/10.2174/0929867323666160210124930 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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