Abstract
A series of macamides (1-4) and their synthetic analogs (5-14) were synthesized and evaluated for in vitro inhibitory activities against breast cancer cell MCF-7. The results of bioactive assay showed that two of the macamides (compound 1 and 4) and one synthetic analog (compound 5) displayed comparable inhibitory activities against MCF-7 cell line, with IC50 values of 29.6, 36.2 and 27.2 µM, respectively.
Keywords: Macamides derivatives, inhibitory activity, MCF-7.
Letters in Drug Design & Discovery
Title:Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7
Volume: 13 Issue: 6
Author(s): Xiao Xia Liang, Cheng Xiong, Min He, Changliang He and Zhongqiong Yin
Affiliation:
Keywords: Macamides derivatives, inhibitory activity, MCF-7.
Abstract: A series of macamides (1-4) and their synthetic analogs (5-14) were synthesized and evaluated for in vitro inhibitory activities against breast cancer cell MCF-7. The results of bioactive assay showed that two of the macamides (compound 1 and 4) and one synthetic analog (compound 5) displayed comparable inhibitory activities against MCF-7 cell line, with IC50 values of 29.6, 36.2 and 27.2 µM, respectively.
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Cite this article as:
Xia Liang Xiao, Xiong Cheng, He Min, He Changliang and Yin Zhongqiong, Synthesis and Biological Evaluation of Macamides Derivatives as Potent Inhibitors of Breast Cancer Cell MCF-7, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/1570180813888160201100814
DOI https://dx.doi.org/10.2174/1570180813888160201100814 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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