Abstract
Gestational diabetes mellitus (GDM) is traditionally defined as hyperglycemia first detected in pregnancy. The risk of GDM is much higher among obese women than in their lean counterparts. An excess of adipose tissue leads to immune and inflammatory responses of both white adipose tissue and the placenta, contributing to systemic inflammation. Although the significance of both obesity and inflammation is relatively well characterized in GDM, the molecular mechanisms involved are not fully defined and require further study. In recent years huge progress has been made in identifying the intracellular signaling pathways involved in the pathophysiology of GDM. However, currently available data regarding inflammation and obesity in women with GDM are still conflicting or incomplete. We discuss selected aspects of the problem and propose future directions for research in the hope of achieving a better understanding of the disease. In particular, this review highlights recent studies exploring molecular alterations related to insulin resistance, inflammation of the adipose tissue and the placenta, lipotoxicity or endotoxemia.
Keywords: Cytokines, gestational diabetes mellitus, inflammation, insulin resistance, lipotoxicity, obesity.
Current Pharmaceutical Biotechnology
Title:An Interplay between Obesity and Inflammation in Gestational Diabetes Mellitus
Volume: 17 Issue: 7
Author(s): Katarzyna E. Skórzyńska-Dziduszko, Żaneta Kimber-Trojnar, Jolanta Patro-Małysza, Anna Olszewska, Tomasz Zaborowski and Teresa Małecka-Massalska
Affiliation:
Keywords: Cytokines, gestational diabetes mellitus, inflammation, insulin resistance, lipotoxicity, obesity.
Abstract: Gestational diabetes mellitus (GDM) is traditionally defined as hyperglycemia first detected in pregnancy. The risk of GDM is much higher among obese women than in their lean counterparts. An excess of adipose tissue leads to immune and inflammatory responses of both white adipose tissue and the placenta, contributing to systemic inflammation. Although the significance of both obesity and inflammation is relatively well characterized in GDM, the molecular mechanisms involved are not fully defined and require further study. In recent years huge progress has been made in identifying the intracellular signaling pathways involved in the pathophysiology of GDM. However, currently available data regarding inflammation and obesity in women with GDM are still conflicting or incomplete. We discuss selected aspects of the problem and propose future directions for research in the hope of achieving a better understanding of the disease. In particular, this review highlights recent studies exploring molecular alterations related to insulin resistance, inflammation of the adipose tissue and the placenta, lipotoxicity or endotoxemia.
Export Options
About this article
Cite this article as:
E. Skórzyńska-Dziduszko Katarzyna, Kimber-Trojnar Żaneta, Patro-Małysza Jolanta, Olszewska Anna, Zaborowski Tomasz and Małecka-Massalska Teresa, An Interplay between Obesity and Inflammation in Gestational Diabetes Mellitus, Current Pharmaceutical Biotechnology 2016; 17 (7) . https://dx.doi.org/10.2174/1389201017666160127105926
DOI https://dx.doi.org/10.2174/1389201017666160127105926 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
An Ethnomedicinal Survey of Antidiabetic Plants and Preliminary Evaluation of Antioxidant, Hypoglycemic Activity <i>Maesa indica</i> Leaves, a Folk Antidiabetic Plant of Manipur, India
Current Traditional Medicine Left Atrial Appendage Closure -The WATCHMAN Device
Current Cardiology Reviews Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions
Current Clinical Pharmacology Patent Selections
Recent Patents on Food, Nutrition & Agriculture Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships
Mini-Reviews in Medicinal Chemistry Relationships of Beta2- and Beta3--Adrenoceptor Polymorphisms with Obesity, Hypertension and Metabolic Syndrome
Current Hypertension Reviews Cardiomyopathy of Pregnancy
Current Women`s Health Reviews Recent Medicinal Chemistry Approach for the Development of Dipeptidyl Peptidase IV Inhibitors
Current Medicinal Chemistry Tetrahydrobiopterin Biosynthesis, Utilization and Pharmacological Effects
Current Drug Metabolism The Emerging Diabetes Online Community
Current Diabetes Reviews Editorial: [Hot topic: Weight Gain Management and Nutritional Education Throughout Pregnancy (Guest Editor: Hiroko Watanabe)]
Current Women`s Health Reviews Bisphenol A as a Factor in the Mosaic of Autoimmunity
Endocrine, Metabolic & Immune Disorders - Drug Targets Processed Foods, Dysbiosis, Systemic Inflammation, and Poor Health
Current Nutrition & Food Science Prevalence of Latent Tuberculosis (LTB) Among Pregnant Women in a High Burden Setting in Sudan using Interferon Gamma (IFN- γ) Releasing Assay (IGRA)
Current Women`s Health Reviews Fluoride Interactions: From Molecules to Disease
Current Signal Transduction Therapy Mesenchymal Stromal Cells from Umbilical Cord Blood
Current Stem Cell Research & Therapy Hyperandrogenism, Insulin Resistance and Hyperinsulinemia as Cardiovascular Risk Factors in Diabetes Mellitus
Current Diabetes Reviews Functions of S100 Proteins
Current Molecular Medicine Genetics in Gestational Diabetes Mellitus: Association with Incidence, Severity, Pregnancy Outcome and Response to Treatment
Current Diabetes Reviews Low Birth Weight and Risk of Obesity - A Potential Problem for the Japanese People
Current Women`s Health Reviews