Generic placeholder image

Reviews on Recent Clinical Trials

Editor-in-Chief

ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Research Article

Alcoholic Liver Disease and Hepatitis C Chronic Infection

Author(s): Alessandro Federico, Marcello Dallio, Vittorio M. Ormando, Ludovico Abenavoli, Mario Masarone, Marcello Persico and Carmela Loguercio

Volume 11, Issue 3, 2016

Page: [201 - 207] Pages: 7

DOI: 10.2174/1574887111666160126144940

Price: $65

Abstract

Alcoholic and virus C hepatitis currently represent the main causes of chronic liver disease worldwide. Every year many people die and are subjected to complex hospitalization and medical assistance due to these pathologies. Alcoholic liver disease and hepatitis C virus chronic infection are often present in the same patient. These two pathologies sinergically act in determining the onset and progression of liver damage that, from the chronic hepatitis staging, may rapidly progress to fibrosis, cirrhosis and hepatocellular carcinoma. In this review we analysed physiopathological aspects and biomolecular interactions that relate ethanol and hepatitis C virus in determining liver damage; moreover we took into account the effect on the natural history of liver disease deriving from the co-presence of these pathologies. Therefore we paid particular attention to the ability of ethanol and hepatitis C virus to in inducing oxidative stress or lipid accumulation, and analyzed the basic mechanisms of fibrogenesis that both diseases have got, amplified by their co-presence in the same patient. Finally we paid attention to the oncogenetic mechanisms inducing hepatocellular carcinoma and variability of response to antiviral therapy that derives from alcohol abuse in a subject affected by C hepatitis.

Keywords: Antiviral therapy, ethanol, hepatitis C virus, hepatocellular carcinoma, liver chirrosis, oxidative stress.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy