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Current Drug Delivery

Editor-in-Chief

ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Review Article

Nanosuspension: Principles, Perspectives and Practices

Author(s): Sachin Kumar Singh, Yogyata Vaidya, Monica Gulati, Sibasis Bhattacharya, Varun Garg and Narendra Kumar Pandey

Volume 13, Issue 8, 2016

Page: [1222 - 1246] Pages: 25

DOI: 10.2174/1567201813666160101120452

Price: $65

Abstract

In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions offer versatile features and unique advantages over other approaches that have been utilized for this purpose. The unique inherent properties of nanosuspensions have been explored for a wide variety of applications. Commercial production of stable nanosuspensions has been made possible by the use of techniques such as media milling and high pressure homogenization. This article reviews various techniques being employed for production, characterization, merits and limitations of nanosuspensions and mechanisms that play a role in the physicochemical stability of nanosuspensions. The common strategies applied so far to overcome their stability and commercialization related aspects are also highlighted.

Keywords: Bottom up technology, Characterization, High pressure homogenization, Media milling, Nanosuspension, Stability.

Graphical Abstract

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