Abstract
The development of multifunctional theranostic agents has become an intriguing venture for personalized oncology, because they can integrate tumor diagnosis and therapy. One approach explored to obtain such multifunctional theranostic agents is through the chemical conjugation of anticancer drugs and contrast agents with various cancer-targeted ligands. The other approach is based on the nanoplatform, in which cancer-targeted nanostructures achieve simultaneous cancer specific detection and therapeutics either by EPR effect or by conjugation of target ligands. Interestingly, a newly emerging strategy from multifunctional small molecules to develop cancertargeted theranostic agents has been reported recently. In consideration of the urgent need and rapid development of theranostic agents in cancer therapy, herein we review the currently adopted and newly emerging approaches for their preparation, and highlight the promises and challenges in each approach, hoping to offer useful insights in developing more specific and efficient cancer theranostic agents suitable for clinical use.
Keywords: Cancer theranostics, multifunctional agents, near-infrared imaging, cyanine dyes, nanotheranostic agents.
Current Medicinal Chemistry
Title:Newly Emerging Theranostic Agents for Simultaneous Cancertargeted Imaging and Therapy
Volume: 23 Issue: 5
Author(s): Shenglin Luo, Xiaochao Yang and Chunmeng Shi
Affiliation:
Keywords: Cancer theranostics, multifunctional agents, near-infrared imaging, cyanine dyes, nanotheranostic agents.
Abstract: The development of multifunctional theranostic agents has become an intriguing venture for personalized oncology, because they can integrate tumor diagnosis and therapy. One approach explored to obtain such multifunctional theranostic agents is through the chemical conjugation of anticancer drugs and contrast agents with various cancer-targeted ligands. The other approach is based on the nanoplatform, in which cancer-targeted nanostructures achieve simultaneous cancer specific detection and therapeutics either by EPR effect or by conjugation of target ligands. Interestingly, a newly emerging strategy from multifunctional small molecules to develop cancertargeted theranostic agents has been reported recently. In consideration of the urgent need and rapid development of theranostic agents in cancer therapy, herein we review the currently adopted and newly emerging approaches for their preparation, and highlight the promises and challenges in each approach, hoping to offer useful insights in developing more specific and efficient cancer theranostic agents suitable for clinical use.
Export Options
About this article
Cite this article as:
Luo Shenglin, Yang Xiaochao and Shi Chunmeng, Newly Emerging Theranostic Agents for Simultaneous Cancertargeted Imaging and Therapy, Current Medicinal Chemistry 2016; 23 (5) . https://dx.doi.org/10.2174/0929867323666151223095718
DOI https://dx.doi.org/10.2174/0929867323666151223095718 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Lycopene Modulation of Molecular Targets Affected by Smoking Exposure
Current Cancer Drug Targets SCYL1-BP1 Affects Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells via Cyclin F and RRM2
Anti-Cancer Agents in Medicinal Chemistry Editorial: [Hot topic: The Metabolism of Nanotechnology-Based Drugs (Guest Editors: Ming-Fa Hsieh and Chun-Ming Huang)]
Current Drug Metabolism IP6 & Inositol in Cancer Prevention and Therapy
Current Cancer Therapy Reviews Towards an Experimental and Systems Biology Framework for Cancer Cell Therapeutics
Current Bioinformatics Data Integration in Functional Analysis of MicroRNAs
Current Bioinformatics Large Porous Hollow Particles: Lightweight Champions of Pulmonary Drug Delivery
Current Pharmaceutical Design The Role of Estrogen and Estrogen-Related Drugs in Cardiovascular Diseases
Current Drug Metabolism The Adipocyte as a Novel TSH Target
Mini-Reviews in Medicinal Chemistry Calpains: Attractive Targets for the Development of Synthetic Inhibitors
Current Topics in Medicinal Chemistry Honey, Health and Longevity
Current Aging Science Functional Evaluation of Imatinib mesylate in Hepatocellular Carcinoma Cells
Recent Patents on Biomarkers Diagnostic Performance of Magnetic Resonance Cholangiopancreatography (MRCP) for Biliopancreatic Cancer
Current Medical Imaging Is Brain-Derived Neurotrophic Factor: A Common Link Between Neurodegenerative Disorders and Cancer?
Current Alzheimer Research Impact of Sex Hormone Metabolism on the Vascular Effects of Menopausal Hormone Therapy in Cardiovascular Disease
Current Drug Metabolism Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders
Current Neuropharmacology A Novel Treatment Strategy for Sepsis and Septic Shock Based on the Interactions between Prostanoids, Nitric Oxide, and 20-Hydroxyeicosatetraenoic Acid
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry A Comprehensive Patent Review on β-cyclodextrin Cross-linked Nanosponges for Multiple Applications
Recent Patents on Nanotechnology The Metabolic Fate of Apple Polyphenols in Humans
Current Nutrition & Food Science Editorial (Thematic Issue: Polymeric Nanomedicines for Malignancy Therapy)
Current Pharmaceutical Biotechnology