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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Brønsted Acid Catalyzed Peptide Synthesis through Azlactone Rings

Author(s): Pedro P. De Castro, Igor F. Dos Santos and Giovanni W. Amarante

Volume 13, Issue 3, 2016

Page: [440 - 444] Pages: 5

DOI: 10.2174/1570179413999151211114542

Price: $65

Abstract

Brønsted acid catalyzed azlactone ring opening by amino acids leading to the synthesis of dipeptides is presented. Eleven compounds were synthesized in good to excellent isolated yields. Catalyst loading revealed that 5.0 mol % of (+/-)-CSA as an organocatalyst, under room temperature for 24 h, was suitable to promote this transformation.

Keywords: Azlactones, peptides, amino acids, organocatalysis, Brønted acid, (+/-)-camphorsulfonic acid.


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