Updated Report on Synthesis and Biological Properties of Oxadiazine-Based Heterocyclic Derivatives

Abstract

Oxadiazine scaffold-based compounds are undoubtedly an important class of heterocyclic derivatives, which always present diverse bioactivities including cardiovascular, antitumor, antiviral, anti-leishmanial, antibacterial, antimicrobial, monoamine oxidase inhibition, acricidal, insecticidal, plant-growth regulating activities and chitin biosynthesis inhibitions. With the development of organic synthesis, versatile features of oxadiazine ring have emerged, so here we have reviewed the recent advances of oxadiazine-based heterocyclic derivatives mainly including preparation, transformation and biological properties, and this report is also an updated version of our previous review with modifications.

Keywords: Oxadiazine, oxadiazinone, heterocyclic scaffold, synthetic method, pharmaceutical activity, pesticidal activity, biological application.

Cite as