Abstract
Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.
Keywords: Bleomycin, electrochemotherapy, liposomes, microsphere, nanoparticles, photochemical internalization, targeted drug delivery, ultrasound.
Current Cancer Drug Targets
Title:Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review
Volume: 16 Issue: 6
Keywords: Bleomycin, electrochemotherapy, liposomes, microsphere, nanoparticles, photochemical internalization, targeted drug delivery, ultrasound.
Abstract: Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.
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Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review, Current Cancer Drug Targets 2016; 16 (6) . https://dx.doi.org/10.2174/1568009616666151130213910
DOI https://dx.doi.org/10.2174/1568009616666151130213910 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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