Abstract
It was estimated that small cell lung cancer (SCLC) accounts for about one Sixth of all lung cancer cases. Patients with SCLC are usually diagnosed in advanced stage of disease. Unfortunately at this stage, prognosis is very poor. Bevacizumab is a monoclonal antibody against VEGF, which inhibits the angiogenesis in malignant tumors. Although Bevacizumab has been approved for firstline use in advanced non-SCLC, the first report has been available for its use in SCLC. In this review, we summarized all available data on the use of Bev in SCLC patients. Finally, future directions are discussed.
Keywords: Bevacizumab, lung cancer, maintenance, small cell.
Current Cancer Drug Targets
Title:Is there a Place for Bevacizumab in Patients with Extensive-Stage Small Cell Lung Cancer?
Volume: 16 Issue: 3
Author(s): Giandomenico Roviello and Daniele Generali
Affiliation:
Keywords: Bevacizumab, lung cancer, maintenance, small cell.
Abstract: It was estimated that small cell lung cancer (SCLC) accounts for about one Sixth of all lung cancer cases. Patients with SCLC are usually diagnosed in advanced stage of disease. Unfortunately at this stage, prognosis is very poor. Bevacizumab is a monoclonal antibody against VEGF, which inhibits the angiogenesis in malignant tumors. Although Bevacizumab has been approved for firstline use in advanced non-SCLC, the first report has been available for its use in SCLC. In this review, we summarized all available data on the use of Bev in SCLC patients. Finally, future directions are discussed.
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Cite this article as:
Roviello Giandomenico and Generali Daniele, Is there a Place for Bevacizumab in Patients with Extensive-Stage Small Cell Lung Cancer?, Current Cancer Drug Targets 2016; 16 (3) . https://dx.doi.org/10.2174/1568009616666151106120716
DOI https://dx.doi.org/10.2174/1568009616666151106120716 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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