Abstract
The potential of metabolites to contribute to drug-drug interactions (DDIs) has not been well defined so far. However, metabolites of parent drug compounds can contribute to both side effects and DDIs. To address this unmet challenge, we introduce recent advances as well as our perspectives of the metabolites in DDIs in this review. Firstly, we review several typical examples of organic small molecule drug metabolites asmajor contributors to DDIs in clinic. Since some of the metabolites are so important in the contributions to DDIs, we then further review how to identify active metabolites in vivo and when such metabolites should trigger DDI assessment. Lastly, we review in vivo animal models, especially humanized/chimeric mice, in improving the quality of preclinical DDI assessments.
Keywords: Bupropion, drug-drug interactions (DDIs), gemfibrozil, metabolites, pharmacodynamics, pharmacokinetics.
Current Organic Chemistry
Title:Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions
Volume: 20 Issue: 17
Author(s): Liqian Gao, Jun Chen, Yi Hu, Hongyan Sun, Yong Siang Ong, Jingxin Zhang, Zhifang Chai and Su Seong Lee
Affiliation:
Keywords: Bupropion, drug-drug interactions (DDIs), gemfibrozil, metabolites, pharmacodynamics, pharmacokinetics.
Abstract: The potential of metabolites to contribute to drug-drug interactions (DDIs) has not been well defined so far. However, metabolites of parent drug compounds can contribute to both side effects and DDIs. To address this unmet challenge, we introduce recent advances as well as our perspectives of the metabolites in DDIs in this review. Firstly, we review several typical examples of organic small molecule drug metabolites asmajor contributors to DDIs in clinic. Since some of the metabolites are so important in the contributions to DDIs, we then further review how to identify active metabolites in vivo and when such metabolites should trigger DDI assessment. Lastly, we review in vivo animal models, especially humanized/chimeric mice, in improving the quality of preclinical DDI assessments.
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Cite this article as:
Gao Liqian, Chen Jun, Hu Yi, Sun Hongyan, Siang Ong Yong, Zhang Jingxin, Chai Zhifang and Seong Lee Su, Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions, Current Organic Chemistry 2016; 20 (17) . https://dx.doi.org/10.2174/1385272820666151102212542
DOI https://dx.doi.org/10.2174/1385272820666151102212542 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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