Abstract
Background: It is well established that there is an important genetic predisposition for type 2 diabetes mellitus (T2DM).
Objective: To summarise available epidemiological data regarding T2DM transmission in various populations.
Method: Narrative review.
Results: The estimated risk for the diagnosis of T2DM increases approximately by 2-4 times, when father, mother or both have this condition. Conversely, many T2DM patients have family members with DM. Studies have suggested that the likelihood of T2DM in the next generation is higher in the event of a diabetic mother than father. Both genetic factors, such as mitochondrial DNA mutations, and environmental components, such as intra-uterine environment, have been implicated in the higher maternal transmission of T2DM. Despite the above findings, some studies in populations with high frequency of T2DM have not corroborated the predominantly maternal transmission. Such works have shown either an excess paternal or an equal transmission of T2DM.
Conclusion: It appears that potential biases in reporting family history data, especially between the various racial groups, have contributed to the controversy over the existence of excess maternal transmission of DM.
Keywords: Family history, maternal diabetes, paternal diabetes, type 2 diabetes mellitus.
Current Diabetes Reviews
Title:Family History of Type 2 Diabetes: Does Having a Diabetic Parent Increase the Risk?
Volume: 13 Issue: 1
Author(s): A. K. Papazafiropoulou, N. Papanas, A. Melidonis and E. Maltezos
Affiliation:
Keywords: Family history, maternal diabetes, paternal diabetes, type 2 diabetes mellitus.
Abstract: Background: It is well established that there is an important genetic predisposition for type 2 diabetes mellitus (T2DM).
Objective: To summarise available epidemiological data regarding T2DM transmission in various populations.
Method: Narrative review.
Results: The estimated risk for the diagnosis of T2DM increases approximately by 2-4 times, when father, mother or both have this condition. Conversely, many T2DM patients have family members with DM. Studies have suggested that the likelihood of T2DM in the next generation is higher in the event of a diabetic mother than father. Both genetic factors, such as mitochondrial DNA mutations, and environmental components, such as intra-uterine environment, have been implicated in the higher maternal transmission of T2DM. Despite the above findings, some studies in populations with high frequency of T2DM have not corroborated the predominantly maternal transmission. Such works have shown either an excess paternal or an equal transmission of T2DM.
Conclusion: It appears that potential biases in reporting family history data, especially between the various racial groups, have contributed to the controversy over the existence of excess maternal transmission of DM.
Export Options
About this article
Cite this article as:
Papazafiropoulou K. A., Papanas N., Melidonis A. and Maltezos E., Family History of Type 2 Diabetes: Does Having a Diabetic Parent Increase the Risk?, Current Diabetes Reviews 2017; 13 (1) . https://dx.doi.org/10.2174/1573399812666151022143502
DOI https://dx.doi.org/10.2174/1573399812666151022143502 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Anti-Inflammatory Potential of ACE2/Angiotensin-(1-7)/Mas Receptor Axis: Evidence from Basic and Clinical Research
Current Drug Targets P2Y Purinoceptors as Potential Emerging Therapeutical Target in Vascular Disease
Current Pharmaceutical Design Transient Elastography in HIV Infected Patients with Liver Steatosis Identifies a High-Risk Group for Non-Alcoholic Steatohepatitis
Current HIV Research “Metabolically Healthy” Obesity: Fact or Threat?
Current Diabetes Reviews New Chemotherapy and Immunotherapy for Tuberculosis
Current Respiratory Medicine Reviews Recent Patents on Camellia sinensis: Source of Health Promoting Compounds
Recent Patents on Food, Nutrition & Agriculture Fc Engineering to Improve the Function of Therapeutic Antibodies
Current Pharmaceutical Biotechnology Pancreatic Amylin as a Centrally Acting Satiating Hormone
Current Drug Targets Sevoflurane in Intraoperative and Postoperative Cardiac Surgery Patients. Our Experience in Intensive Care Unit with Sevoflurane Sedation
Current Pharmaceutical Design Current Status of Computer-Aided Drug Design for Type 2 Diabetes
Current Computer-Aided Drug Design The Rationale for Comparative Studies of Accelerated Atherosclerosis in Rheumatic Diseases
Current Vascular Pharmacology Peripheral Blood Adipokines and Insulin Levels in Patients with Alzheimer's Disease: A Replication Study and Meta-Analysis
Current Alzheimer Research Development of Insulin Resistance During Aging: Involvement of Central Processes and Role of Adipokines
Current Protein & Peptide Science Fanconi-Bickel Syndrome - A Congenital Defect of Facilitative Glucose Transport
Current Molecular Medicine Nanotechnology Mediated Diagnosis of Type II Diabetes Mellitus
Recent Innovations in Chemical Engineering Seaweed Proteins as a Source of Bioactive Peptides
Current Pharmaceutical Design Continuous Positive Airway Pressure Treatment in Patients with Sleep Apnoea: Does it Really Improve Glucose Metabolism?
Current Diabetes Reviews A Review of Pharmacokinetic Parameters of Metabolites and Prodrugs
Drug Metabolism Letters Directed Differentiation of Pluripotent Cells Towards Therapeutic Stem Cells
Recent Patents on Regenerative Medicine Insights into the Platelet Releasate
Current Pharmaceutical Design