Abstract
Topical and transdermal delivery has been studied over last decades and it presents advantages for the treatment of several disorders, macromolecules delivery and vaccination. The greatest challenge is to overcome the stratum corneum (SC) barrier. Compared to traditional topical formulation strategies, nano /microsystems offer advantages such as increased stability, increased loading dose, coverage of undesired colors, reduced toxicity and prolonged release of active agents. However, there are no conclusive studies demonstrating the ability of such systems to penetrate the skin in relevant therapeutic amounts. The use of physical methods holds great promise for enhancing skin permeation through the SC and for targeting hair follicles. This review discusses the characteristics and feasibility of using a dual approach employing the application of physical methods of permeation enhancement to enable the topical or transdermal delivery of drug-loaded nano/microsystems.
Keywords: Dendrimers, iontophoresis, liposomes, microneedles, nanoparticles, permeation, skin, sonophoresis.
Current Drug Targets
Title:Topical and Transdermal Delivery of Drug-Loaded Nano/ Microsystems with Application of Physical Enhancement Techniques
Volume: 17 Issue: 13
Author(s): Lívia Neves Borgheti-Cardoso, Tamara Ângelo, Guilherme M. Gelfuso, Renata F.V. Lopez and Taís Gratieri
Affiliation:
Keywords: Dendrimers, iontophoresis, liposomes, microneedles, nanoparticles, permeation, skin, sonophoresis.
Abstract: Topical and transdermal delivery has been studied over last decades and it presents advantages for the treatment of several disorders, macromolecules delivery and vaccination. The greatest challenge is to overcome the stratum corneum (SC) barrier. Compared to traditional topical formulation strategies, nano /microsystems offer advantages such as increased stability, increased loading dose, coverage of undesired colors, reduced toxicity and prolonged release of active agents. However, there are no conclusive studies demonstrating the ability of such systems to penetrate the skin in relevant therapeutic amounts. The use of physical methods holds great promise for enhancing skin permeation through the SC and for targeting hair follicles. This review discusses the characteristics and feasibility of using a dual approach employing the application of physical methods of permeation enhancement to enable the topical or transdermal delivery of drug-loaded nano/microsystems.
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Borgheti-Cardoso Neves Lívia, Ângelo Tamara, Gelfuso M. Guilherme, Lopez F.V. Renata and Gratieri Taís, Topical and Transdermal Delivery of Drug-Loaded Nano/ Microsystems with Application of Physical Enhancement Techniques, Current Drug Targets 2016; 17 (13) . https://dx.doi.org/10.2174/1389450116666151019095121
DOI https://dx.doi.org/10.2174/1389450116666151019095121 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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