Abstract
This review surveys the use of pluripotent and multipotent stem cells in skeletal tissue engineering. Specific emphasis is focused on evaluating the function and activities of these cells in the context of development in vivo, and how technologies and methods of stem cell-based tissue engineering for stem cells must draw inspiration from developmental biology. Information on the embryonic origin and in vivo differentiation of skeletal tissues is first reviewed, to shed light on the persistence and activities of adult stem cells that remain in skeletal tissues after embryogenesis. Next, the development and differentiation of pluripotent stem cells is discussed, and some of their advantages and disadvantages in the context of tissue engineering are presented. The final section highlights current use of multipotent adult mesenchymal stem cells, reviewing their origin, differentiation capacity, and potential applications to tissue engineering.
Keywords: Biomaterials, bone, cartilage, cell differentiation, disease model, intervertebral disc, mesenchymal stem cells, pluripotent stem cells, scaffold, skeletal development.
Current Stem Cell Research & Therapy
Title:Stem Cells in Skeletal Tissue Engineering: Technologies and Models
Volume: 11 Issue: 6
Author(s): Mark T. Langhans, Shuting Yu and Rocky S. Tuan
Affiliation:
Keywords: Biomaterials, bone, cartilage, cell differentiation, disease model, intervertebral disc, mesenchymal stem cells, pluripotent stem cells, scaffold, skeletal development.
Abstract: This review surveys the use of pluripotent and multipotent stem cells in skeletal tissue engineering. Specific emphasis is focused on evaluating the function and activities of these cells in the context of development in vivo, and how technologies and methods of stem cell-based tissue engineering for stem cells must draw inspiration from developmental biology. Information on the embryonic origin and in vivo differentiation of skeletal tissues is first reviewed, to shed light on the persistence and activities of adult stem cells that remain in skeletal tissues after embryogenesis. Next, the development and differentiation of pluripotent stem cells is discussed, and some of their advantages and disadvantages in the context of tissue engineering are presented. The final section highlights current use of multipotent adult mesenchymal stem cells, reviewing their origin, differentiation capacity, and potential applications to tissue engineering.
Export Options
About this article
Cite this article as:
T. Langhans Mark, Yu Shuting and S. Tuan Rocky, Stem Cells in Skeletal Tissue Engineering: Technologies and Models, Current Stem Cell Research & Therapy 2016; 11 (6) . https://dx.doi.org/10.2174/1574888X10666151001115248
DOI https://dx.doi.org/10.2174/1574888X10666151001115248 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Genetics of Congenital Heart Disease
Current Cardiology Reviews Recent Advances in the Transition Metal-Catalyzed Addition of Carboxylic Acids to Alkynes
Current Organic Chemistry Robotic Assisted Surgery in Gynecology: Current Insights and Future Perspectives
Recent Patents on Biotechnology Neuromodulation of the Perinatal Respiratory Network
Current Neuropharmacology Conserved Molecular Players for Axon Guidance and Angiogenesis
Current Protein & Peptide Science Plasmid DNA Manufacturing Technology
Recent Patents on Biotechnology Planar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
Current Genomics Congenital Heart Disease: The Crossroads of Genetics, Epigenetics and Environment
Current Genomics A Review of Systemic Vasodilators in Low Cardiac Output Syndrome Following Pediatric Cardiac Surgery
Current Vascular Pharmacology Troponin in Newborns and Pediatric Patients
Cardiovascular & Hematological Agents in Medicinal Chemistry Baculovirus Expression Vectors for Insect and Mammalian Cells
Current Drug Targets Preoperative and Follow up Multi-Detector Row CT Angiography (MDCTA) in the Evaluation of Interrupted Aortic Arch (IAA)
Current Medical Imaging Baculovirus as a Gene Delivery Vector for Cartilage and Bone Tissue Engineering
Current Gene Therapy Prospectives for Gene Therapy of Retinal Degenerations
Current Genomics Neurocognitive Monitoring and Care During Pediatric Cardiopulmonary Bypass — Current and Future Directions
Current Cardiology Reviews Pulmonary Vasodilators in the Management of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery
Current Vascular Pharmacology Impact of Pulmonary Vascular Resistances in Heart Transplantation for Congenital Heart Disease
Current Cardiology Reviews Apis mellifera Proteomics: Where Will the Future Bee?
Current Proteomics Current Management of Traumatic Rupture of the Descending Thoracic Aorta
Current Cardiology Reviews RNA-Mediated Therapeutics: From Gene Inactivation to Clinical Application
Current Topics in Medicinal Chemistry