PLCO: Evolution of an Epidemiologic Resource and Opportunities for Future Studies

Title:PLCO: Evolution of an Epidemiologic Resource and Opportunities for Future Studies

Volume: 10 Issue: 3

Author(s): Amanda Black, Wen-Yi Huang, Patrick Wright, Tom Riley, Jerome Mabie, Sunitha Mathew, Lawrence Ragard, Sigurd Hermansen, Kelly Yu, Paul Pinsky, Philip C. Prorok, Neal D. Freedman and Robert N. Hoover

Affiliation:

Keywords: Cancer research, cohort, epidemiologic resource, PLCO, screening trial.

Abstract: The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), a large-scale, multi-institutional, randomized controlled trial, was launched in 1992 to evaluate the effectiveness of screening modalities for prostate, lung, colorectal, and ovarian cancer. However, PLCO was additionally designed to serve as an epidemiologic resource and the National Cancer Institute has invested substantial resources over the years to accomplish this goal. In this report, we provide a summary of changes to PLCO’s follow-up after conclusion of the screening phase of the trial and highlight recent data and biospecimen collections, including ancillary studies, geocoding, administration of a new medication use questionnaire, consent for linkage to Medicare, and additional tissue collection that enhance the richness of the PLCO resource and provide further opportunities for scientific investigation into the prevention, early detection, etiology and treatment of cancer.

Cite this article as:

Black Amanda, Huang Wen-Yi, Wright Patrick, Riley Tom, Mabie Jerome, Mathew Sunitha, Ragard Lawrence, Hermansen Sigurd, Yu Kelly, Pinsky Paul, Prorok C. Philip, Freedman D. Neal and Hoover N. Robert, PLCO: Evolution of an Epidemiologic Resource and Opportunities for Future Studies, Reviews on Recent Clinical Trials 2015; 10 (3) . https://dx.doi.org/10.2174/157488711003150928130654