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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

An Efficient Organocatalyst for Environmentally benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium

Author(s): Faiza Boukezzoula, Taoues Boumoud, Boudjemaa Boumoud and Abdelmadjid Debache

Volume 12, Issue 10, 2015

Page: [734 - 740] Pages: 7

DOI: 10.2174/1570178612666150924001127

Price: $65

Abstract

The use of multicomponent reactions as potential synthetic processes, ionic liquids as catalysts and water as reaction medium is a suitable approach that respects, in some extent, the requirements of sustainable chemistry. In this context, we report, herein, an efficient and high yielding four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aromatic aldehydes using octyltriphenylphosphonium bromide as an effective and recoverable catalyst and water as solvent under mild reaction conditions.

Keywords: Aqueous medium, ionic liquid, multicomponent reactions, octyltriphenylphosphonium bromide, pyranopyrazoles, rate enhancement, triphenylphosphine.


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