Abstract
Neonates are given many medicines. A significant proportion of these medicines contain excipients. Excipients are used to facilitate the manufacture and use of medicines. Without excipients, it would not be feasible to formulate some drugs into appropriate medicinal products. For others the removal of excipients would reduce the shelf life and make them uneconomic to produce or too expensive for users to purchase.
Excipients are also important because some of them can cause harm. Accordingly, it is important to minimize excipient exposure when possible and to only use them when there is a clear pharmaceutical requirement. On balance it is generally safe to use medicines containing excipients.
This review introduces physicians and nurses to the functions of excipients in medicines and describes some potential adverse effects of excipients in neonates. The review also provides pharmaceutical scientists with an insight to issues that arise when excipients are administered to neonates. The review answers some key questions about excipients, addresses some case studies of excipient use, proposes approaches for clinicians who prescribe and administer medicines containing excipients and identifies areas for research that seeks to establish the safety profiles of excipients in neonates."
Keywords: Neonate, prematurity, excipient, formulation, toxicity, benefit-risk.
Current Pharmaceutical Design
Title:Why are Excipients Important to Neonates?
Volume: 21 Issue: 39
Author(s): Mark A. Turner and Utpal Shah
Affiliation:
Keywords: Neonate, prematurity, excipient, formulation, toxicity, benefit-risk.
Abstract: Neonates are given many medicines. A significant proportion of these medicines contain excipients. Excipients are used to facilitate the manufacture and use of medicines. Without excipients, it would not be feasible to formulate some drugs into appropriate medicinal products. For others the removal of excipients would reduce the shelf life and make them uneconomic to produce or too expensive for users to purchase.
Excipients are also important because some of them can cause harm. Accordingly, it is important to minimize excipient exposure when possible and to only use them when there is a clear pharmaceutical requirement. On balance it is generally safe to use medicines containing excipients.
This review introduces physicians and nurses to the functions of excipients in medicines and describes some potential adverse effects of excipients in neonates. The review also provides pharmaceutical scientists with an insight to issues that arise when excipients are administered to neonates. The review answers some key questions about excipients, addresses some case studies of excipient use, proposes approaches for clinicians who prescribe and administer medicines containing excipients and identifies areas for research that seeks to establish the safety profiles of excipients in neonates."
Export Options
About this article
Cite this article as:
Turner A. Mark and Shah Utpal, Why are Excipients Important to Neonates?, Current Pharmaceutical Design 2015; 21 (39) . https://dx.doi.org/10.2174/1381612821666150901110341
DOI https://dx.doi.org/10.2174/1381612821666150901110341 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Resveratrol Targets in Inflammation
Endocrine, Metabolic & Immune Disorders - Drug Targets Radiosensitizing Effect of Electrochemotherapy: A Systematic Review of Protocols and Efficiency
Current Drug Targets Microglia-Targeted Pharmacotherapy in Retinal Neurodegenerative Diseases
Current Drug Targets Vasopressin in Heart Failure
Endocrine, Metabolic & Immune Disorders - Drug Targets DNA Vaccine and the CNS Axonal Regeneration
Current Pharmaceutical Design Endothelins and the Role of Endothelin Antagonists in the Management of Posttraumatic Vasospasm
Current Pharmaceutical Design Polymorphism in Endothelin-1 Gene: An Overview
Current Clinical Pharmacology Central Nervous System Disorders Associated to Immune Checkpoint Inhibitors
Current Cancer Therapy Reviews Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage
Current Pharmaceutical Design Targeting Water in the Brain: Role of Aquaporin-4 in Ischemic Brain Edema
Current Drug Targets Severe Preeclampsia
Current Women`s Health Reviews Gender Hormones: Role in the Pathogenesis of Central Nervous System Disease and Demyelination
Current Neurovascular Research Teratological Consequences of Nitric Oxide Synthesis Inhibition
Current Pharmaceutical Design Patents on Therapeutic and Cosmetic Applications of Bioactives of Crocus Sativus L. and their Production through Synthetic Biology Methods: A Review
Recent Patents on Biotechnology Current and Future Therapeutic Strategies to Target Inflammation in Stroke
Current Drug Targets - Inflammation & Allergy Involvement of Leukotriene Pathway in the Pathogenesis of Ischemia- Reperfusion Injury and Septic and Non-Septic Shock
Current Vascular Pharmacology Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase Pathways
Current Neuropharmacology Nitric Oxide, Epileptic Seizures, and Action of Antiepileptic Drugs
CNS & Neurological Disorders - Drug Targets The Monoaminergic Tripartite Synapse: A Putative Target for Currently Available Antidepressant Drugs
Current Drug Targets Commentary: Low-Grade Non-Resolving Neuroinflammation: Age Does Matter
CNS & Neurological Disorders - Drug Targets