Abstract
Industrial chemical companies have taken advantage of enzymes for the production of pharmaceuticals by means of nonselective and selective transformations. This review covers recently published chemoenzymatic synthesis of important drugs, focusing on the production of the desired targets with high to excellent yields. Remarkably, biocatalysts have allowed the development of asymmetric processes through different strategies, providing efficient access to challenging substrates that are difficult to obtain by traditional chemical methods. Thus, the action of different classes of non hydrolytic enzymes has been covered, including a wide number of oxidoreductases, lyases and transferases. The importance of using enzymes with synthetic purposes under mild reaction conditions is fully demonstrated in the production of active pharmaceutical ingredients and other organic compounds with interesting biological profiles.
Keywords: Asymmetric synthesis, enzymes, lyases, oxidoreductases, pharmaceuticals, transferases.
Current Organic Chemistry
Title:Native Proteins in Organic Chemistry. Recent Achievements in the use of non Hydrolytic Enzymes for the Synthesis of Pharmaceuticals
Volume: 20 Issue: 11
Author(s): María López-Iglesias, Daniel Méndez-Sánchez and Vicente Gotor-Fernández
Affiliation:
Keywords: Asymmetric synthesis, enzymes, lyases, oxidoreductases, pharmaceuticals, transferases.
Abstract: Industrial chemical companies have taken advantage of enzymes for the production of pharmaceuticals by means of nonselective and selective transformations. This review covers recently published chemoenzymatic synthesis of important drugs, focusing on the production of the desired targets with high to excellent yields. Remarkably, biocatalysts have allowed the development of asymmetric processes through different strategies, providing efficient access to challenging substrates that are difficult to obtain by traditional chemical methods. Thus, the action of different classes of non hydrolytic enzymes has been covered, including a wide number of oxidoreductases, lyases and transferases. The importance of using enzymes with synthetic purposes under mild reaction conditions is fully demonstrated in the production of active pharmaceutical ingredients and other organic compounds with interesting biological profiles.
Export Options
About this article
Cite this article as:
López-Iglesias María, Méndez-Sánchez Daniel and Gotor-Fernández Vicente, Native Proteins in Organic Chemistry. Recent Achievements in the use of non Hydrolytic Enzymes for the Synthesis of Pharmaceuticals, Current Organic Chemistry 2016; 20 (11) . https://dx.doi.org/10.2174/1385272819666150828200510
DOI https://dx.doi.org/10.2174/1385272819666150828200510 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recommendations for the Treatment of Hypertension in Elderly People
Cardiovascular & Hematological Agents in Medicinal Chemistry The Vernakalant Story: How Did It Come to Approval in Europe and What is the Delay in the U.S.A?
Current Cardiology Reviews Losartan Chemistry and Its Effects via AT1 Mechanisms in the Kidney
Current Medicinal Chemistry Therapeutic Medical Hypothermia-A Multispecialty Approach
Recent Patents on Cardiovascular Drug Discovery Tumor Angiogenesis and VEGFR-2: Mechanism, Pathways and Current Biological Therapeutic Interventions
Current Drug Metabolism Early Occurrence Cases of Diabetes Mellitus: Clinical Picture in Two Major Tertiary Care Hospitals in India
Current Diabetes Reviews Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents
Current Medicinal Chemistry Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19
Current Drug Targets Cardiovascular-Related
Current Bioactive Compounds The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinsons Disease
CNS & Neurological Disorders - Drug Targets ATP-Sensitive Potassium Channels
Current Pharmaceutical Design Annona sp: Plants with Multiple Applications as Alternative Medicine - A Review
Current Bioactive Compounds Enhanced Anticancer Activity and Apoptosis Effect of Bioactive Compound Quercetin Extracted from <i>Ocimum sanctum</i> Leaves
Current Nanomedicine Transactivation of ErbB Receptors by Leptin in the Cardiovascular System: Mechanisms, Consequences and Target for Therapy
Current Pharmaceutical Design Chemical Constituents and Biological Activities of Cordia myxa L.: A Review
The Natural Products Journal Excitotoxic Mechanisms in Non-Motor Dysfunctions and Levodopa- Induced Dyskinesia in Parkinson's Disease: The Role of the Interaction Between the Dopaminergic and the Kynurenine System
Current Medicinal Chemistry Concise Review of the Rationale for Pulmonary Embolism Treatment and Endovascular Device Therapies
Current Cardiology Reviews A Multicenter, Double-Blind, Placebo-Controlled Trial of the PDE9A Inhibitor, PF-04447943, in Alzheimer's Disease
Current Alzheimer Research Study of Convolvulus pluricaulis for Antioxidant and Anticonvulsant Activity
Central Nervous System Agents in Medicinal Chemistry Current Key Points in Management for Severe Community-Acquired Pneumonia
Current Respiratory Medicine Reviews