Abstract
The essential oil of Callitris intratropica is composed to a considerable proportion of rather unique lactones like callitrin (I), callitrisin (II) and columellarin (III) (Fig. 1) [1-7]. During the investigation of the volatiles obtained by hydrodistillation of the wood of this Cupressaceae species [8] we noticed that the oil yield increases with distillation time while the oil composition is shifted more and more towards the high boiling components. To find the reason for this behavior some wood was extracted in a Soxhlet apparatus and the resulting red-brown resinous oil analyzed by GC-MS-FID on a short GC column. The lignans deoxypodorhizon (IV) and deoxypodophyllotoxin (V) [9 -11] were disclosed and present in rather large amounts. Since the wood is available in large quantities this finding points out a new rich source [12 - 14] of these potent bioactive lignans.
Keywords: Callitris intratropica, ethanol extract, chemical composition, lignans, deoxypodophyllotoxin, deoxypodorhizon.
Current Bioactive Compounds
Title:Callitris intratropica R.T. Baker & H.G. Smith as a Novel Rich Source of Deoxypodophyllotoxin
Volume: 11 Issue: 2
Author(s): Juergen Wanner, Leopold Jirovetz and Erich Schmidt
Affiliation:
Keywords: Callitris intratropica, ethanol extract, chemical composition, lignans, deoxypodophyllotoxin, deoxypodorhizon.
Abstract: The essential oil of Callitris intratropica is composed to a considerable proportion of rather unique lactones like callitrin (I), callitrisin (II) and columellarin (III) (Fig. 1) [1-7]. During the investigation of the volatiles obtained by hydrodistillation of the wood of this Cupressaceae species [8] we noticed that the oil yield increases with distillation time while the oil composition is shifted more and more towards the high boiling components. To find the reason for this behavior some wood was extracted in a Soxhlet apparatus and the resulting red-brown resinous oil analyzed by GC-MS-FID on a short GC column. The lignans deoxypodorhizon (IV) and deoxypodophyllotoxin (V) [9 -11] were disclosed and present in rather large amounts. Since the wood is available in large quantities this finding points out a new rich source [12 - 14] of these potent bioactive lignans.
Export Options
About this article
Cite this article as:
Wanner Juergen, Jirovetz Leopold and Schmidt Erich, Callitris intratropica R.T. Baker & H.G. Smith as a Novel Rich Source of Deoxypodophyllotoxin, Current Bioactive Compounds 2015; 11 (2) . https://dx.doi.org/10.2174/157340721102150820124412
DOI https://dx.doi.org/10.2174/157340721102150820124412 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Novel Chemotherapeutic Agents - The Contribution of Scorpionates
Current Medicinal Chemistry Approaches Used in Immunotherapy for Prostate Cancer
Current Cancer Therapy Reviews Cell-Selective Mitochondrial Targeting: Progress in Mitochondrial Medicine
Current Drug Delivery The Clinical Applications of Heat Shock Protein Inhibitors in Cancer - Present and Future
Current Cancer Drug Targets Epigenetics in Cystic Fibrosis: Epigenetic Targeting of a Genetic Disease
Current Drug Targets LncRNA SNHG7 Serves as a Potential Biomarker on the Prognosis of Human Solid Tumors: A Meta-Analysis
Current Pharmaceutical Biotechnology The ABCA2 Transporter: Intracellular Roles in Trafficking and Metabolism of LDL-Derived Cholesterol and Sterol-Related Compounds
Current Drug Metabolism Study of the Usefulness of Bone Scan Index Calculated From 99m-Technetium- Hydroxymethylene Diphosphonate (<sup>99m</sup>Tc-HMDP) Bone Scintigraphy for Bone Metastases from Prostate Cancer Using Deep Learning Algorithms
Current Medical Imaging Cyclooxygenase-2: Potential Role in Regulation of Drug Efflux and Multidrug Resistance Phenotype
Current Pharmaceutical Design MicroRNA and Multiple Myeloma: from Laboratory Findings to Translational Therapeutic Approaches
Current Pharmaceutical Biotechnology Targeting c-MET/HGF Signaling Pathway in Upper Gastrointestinal Cancers: Rationale and Progress
Current Drug Targets The Many Faces of Glutathione Transferase Pi
Current Molecular Medicine Recent Progress of Src SH2 and SH3 Inhibitors as Anticancer Agents
Current Medicinal Chemistry Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy
Current Pharmaceutical Design Exploration of Angiotensin II Type 1 Receptor Modulators by Molecular Fingerprints and Docking Simulations
Letters in Drug Design & Discovery Kinases as Upstream Regulators of the HIF System: Their Emerging Potential as Anti-Cancer Drug Targets
Current Pharmaceutical Design Synthesis, Molecular Docking and Pharmacological Study of Pyrimidothiadiazinones and its bis-derivatives
Letters in Drug Design & Discovery Passive and Active Tumour Targeting with Nanocarriers
Current Drug Discovery Technologies An Overview on Different Classes of Viral Entry and Respiratory Syncitial Virus (RSV) Fusion Inhibitors
Current Medicinal Chemistry The Design of Vectors for RNAi Delivery System
Current Pharmaceutical Design