Abstract
Hydrolases are versatile enzymes for synthetic purposes as they are able to catalyze multiple transformations in both aqueous medium and organic solvents. Their easiness of use and lack of cofactor dependency have attracted the attention of many organic chemists, which have successfully applied this family of enzymes in hydrolytic and reverse synthetic reactions. In this review, the authors have focused on the recent application of hydrolases for the synthesis of active pharmaceutical ingredients and different families of compounds with exceptional biological profiles. Thus, their action has been classified in non-selective and selective transformations including regio- and stereoselective processes. Asymmetric transformations are presented as key issues for the production of drug enantiomers, so examples of hydrolase-catalyzed kinetic resolutions, dynamic kinetic resolutions and desymmetrizations will be extensively discussed, presenting hydrolases as very versatile enzymes for the development of scalable synthetic transformations towards pharmaceuticals.
Keywords: Asymmetric synthesis, biotransformations, desymmetrization, hydrolases, kinetic resolutions, pharmaceuticals.
Current Organic Chemistry
Title:Hydrolases in Organic Chemistry. Recent Achievements in the Synthesis of Pharmaceuticals
Volume: 20 Issue: 11
Author(s): Daniel Méndez-Sánchez, María López-Iglesias and Vicente Gotor-Fernández
Affiliation:
Keywords: Asymmetric synthesis, biotransformations, desymmetrization, hydrolases, kinetic resolutions, pharmaceuticals.
Abstract: Hydrolases are versatile enzymes for synthetic purposes as they are able to catalyze multiple transformations in both aqueous medium and organic solvents. Their easiness of use and lack of cofactor dependency have attracted the attention of many organic chemists, which have successfully applied this family of enzymes in hydrolytic and reverse synthetic reactions. In this review, the authors have focused on the recent application of hydrolases for the synthesis of active pharmaceutical ingredients and different families of compounds with exceptional biological profiles. Thus, their action has been classified in non-selective and selective transformations including regio- and stereoselective processes. Asymmetric transformations are presented as key issues for the production of drug enantiomers, so examples of hydrolase-catalyzed kinetic resolutions, dynamic kinetic resolutions and desymmetrizations will be extensively discussed, presenting hydrolases as very versatile enzymes for the development of scalable synthetic transformations towards pharmaceuticals.
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Cite this article as:
Méndez-Sánchez Daniel, López-Iglesias María and Gotor-Fernández Vicente, Hydrolases in Organic Chemistry. Recent Achievements in the Synthesis of Pharmaceuticals, Current Organic Chemistry 2016; 20 (11) . https://dx.doi.org/10.2174/1385272819666150819190956
DOI https://dx.doi.org/10.2174/1385272819666150819190956 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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