Abstract
Separation of five -blocker 1-fluoro-2,4-dinitrophenyl-5-L-valine amide (FVDA) derivatives i.e. acebutolol, atenolol, metoprolol, oxprenolol and pindolol by means of high-performance thin layer chromatography (HPTLC) as well as pressurized planar electrochromatography (PPEC) techniques and with the use of HPTLC RP-18W plates as well as the acetonitrile - buffer mobile phase is presented.
The influence of concentration of acetonitrile and pH of the mobile phase buffer, and temperature on migration distance of the solute zones was investigated. It has been observed that an increase of acetonitrile content of the mobile phase affects the solute zone migrations and retentions in HPTLC and PPEC. Whereas rise of eluent buffer pH enhances predominantly the isomer migration distances in PPEC. The temperature increase results the enhancement of solute migration distances in PPEC and diminishes isomer retention in HPTLC. Moreover, it improves the diastereomer pair zones resolution in both investigated systems. What is more, the separation selectivity in PPEC and HPTLC system differs. The former system presents higher efficiency in comparison with the latter.
In addition separation of FVDA-oxprenolol and FVDA-pindolol isomers is presented for the first time.
Keywords: Diastereomers, amino alcohols, separation, variables, HPTLC, PPEC.
Call for Papers in Thematic Issues
Advancements in biomedicine, corrosion inhibition/monitoring, and lubrication of carbon dots
Carbon dots, a class of carbon-based nanomaterials, have garnered substantial interest in various scientific and engineering fields due to their unique properties, including excellent optical properties, outstanding biocompatibility, easy preparation, good dispersity, ultrasmall size, low toxicity and environmental friendliness. This special issue of Current Analytical Chemistry aims to showcase cutting-edge ...read more
Applications of artificial intelligence in chemical analysis
Artificial intelligence (AI) has demonstrated its versatility in almost all scientific fields, especially analytical chemistry, which is leading the way in the integration of AI. According to Chemical Abstract Services, one of the major disciplines contributing to AI-related publications and patents is analytical chemistry. That?s because techniques such as deep ...read more
Bioanalytical and Biosensor Technologies for Target Molecules
Bioanalytical and biosensor technologies constitute the core of detecting and sensing diverse molecules within living organisms, encompassing proteins, DNA, small molecular metabolites, and beyond. These molecules assume pivotal roles in biological processes, rendering their analysis and sensing indispensable for comprehending biological phenomena and unraveling disease mechanisms. In the current landscape ...read more
Biogeochemistry: global environmental research and management
his issue focuses on the bio-pathways of trace elements (Ni, Co, Cr, Mn, Cd, Pb, Zn and REE) in soil, plant and atmospheric systems. Specific interest in the application of phytotechnologies that utilise hyperaccumulator plants (agro/phytomining). On the basis of understanding the migration and transformation of trace elements in ecosystem, ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Combinatorial Chemistry & High Throughput Screening
Current Medicinal Chemistry
The Natural Products Journal
Current Catalysis
Current Chinese Chemistry
Current Chinese Science
Current Topics in Chemistry
Related Books
Botanicals and Natural Bioactives: Prevention and Treatment of Diseases
Biosurfactants: A Boon to Healthcare, Agriculture & Environmental Sustainability
Frontiers in Computational Chemistry
Advances in Dye Degradation
Biological and Medical Significance of Chemical Elements
Frontiers In Medicinal Chemistry
Advances in Organic Synthesis
Frontiers in Natural Product Chemistry
Recent Advances in Analytical Techniques
Advanced Catalysts Based on Metal-organic Frameworks (Part 2)
31
1
1
1