Nano-Structured Pyrophosphate Na₂CaP₂O₇ as Catalyst for Selective Synthesis of 1,2-Disubstituted Benzimidazoles in Pure Water

Title:Nano-Structured Pyrophosphate Na₂CaP₂O₇ as Catalyst for Selective Synthesis of 1,2-Disubstituted Benzimidazoles in Pure Water

Volume: 19 Issue: 21

Author(s): Karim Dänoun, Ilham Jioui, Mohamed Bouhrara, Mohamed Zahouily, Abderrahim Solhy, Mustapha Jouiad, Christophe Len and Aziz Fihri

Affiliation:

Keywords: Green chemistry, heterogeneous catalysis, benzimidazoles, diaminoarene, aldehydes, recyclable catalyst.

Abstract: We report on synthesis of 1,2-disubstituted benzimidazoles in pure water using nano-structured pyrophosphate Na₂CaP₂O₇. Our findings showed that this heterogeneous catalyst exhibited high catalytic activity and high selectivity in the synthesis of 1,2- disubstituted benzimidazoles from direct cyclocondensation of aromatic aldehydes with substituted benzene-1,2-diamine in pure water. The salient benefits of this method rely on various factors namely: a simple procedure, mildness of the reaction conditions, short reaction times, operational simplicity, high chemoselectivity, low cost and recyclability of the catalyst.

Cite this article as:

Dänoun Karim, Jioui Ilham, Bouhrara Mohamed, Zahouily Mohamed, Solhy Abderrahim, Jouiad Mustapha, Len Christophe and Fihri Aziz, Nano-Structured Pyrophosphate Na₂CaP₂O₇ as Catalyst for Selective Synthesis of 1,2-Disubstituted Benzimidazoles in Pure Water, Current Organic Chemistry 2015; 19 (21) . https://dx.doi.org/10.2174/1385272819666150807190728