Abstract
Epilepsy is a serious brain condition characterized by recurring seizures. It affects millions of people across the globe. Much advancement in the past has improved the understanding of the underlying pathophysiology and risk factors for epilepsy. These advances have led to the development of both new terminologies and classification as well as treatment strategies for the disease. Despite the fact that various antiepileptic drugs have been developed in past decades, major part of affected population remains either resistant or refractory to the currently available therapy. Also, none of these anticonvulsant agents are devoid of serious side effect. Therefore, constant efforts are being made to develop antiepileptic drugs with improved efficacy and better pharmacokinetic and safety profile. The new structural classes which are being developed broadly amides, amino acids and a number of heterocyclic agents like oxadiazoles, benzimidazoles, benzothazoles, pyrazoles, indoles and benzothaizoles etc. These new compounds have potential for identification of novel targets and drug development. This review makes a note of these issues and describes recent developments in antiepileptic drug discovery.
Keywords: Antiepileptic drugs, epilepsy, heterocycles, seizure, tonic-clonic.
Mini-Reviews in Medicinal Chemistry
Title:Past, Present and Future of Antiepileptic Drug Therapy - Finding a Place for Heterocyclics
Volume: 15 Issue: 12
Author(s): Ruhi Ali, Mohammad Ahmed Khan and Nadeem Siddiqui
Affiliation:
Keywords: Antiepileptic drugs, epilepsy, heterocycles, seizure, tonic-clonic.
Abstract: Epilepsy is a serious brain condition characterized by recurring seizures. It affects millions of people across the globe. Much advancement in the past has improved the understanding of the underlying pathophysiology and risk factors for epilepsy. These advances have led to the development of both new terminologies and classification as well as treatment strategies for the disease. Despite the fact that various antiepileptic drugs have been developed in past decades, major part of affected population remains either resistant or refractory to the currently available therapy. Also, none of these anticonvulsant agents are devoid of serious side effect. Therefore, constant efforts are being made to develop antiepileptic drugs with improved efficacy and better pharmacokinetic and safety profile. The new structural classes which are being developed broadly amides, amino acids and a number of heterocyclic agents like oxadiazoles, benzimidazoles, benzothazoles, pyrazoles, indoles and benzothaizoles etc. These new compounds have potential for identification of novel targets and drug development. This review makes a note of these issues and describes recent developments in antiepileptic drug discovery.
Export Options
About this article
Cite this article as:
Ali Ruhi, Khan Ahmed Mohammad and Siddiqui Nadeem, Past, Present and Future of Antiepileptic Drug Therapy - Finding a Place for Heterocyclics, Mini-Reviews in Medicinal Chemistry 2015; 15 (12) . https://dx.doi.org/10.2174/138955751512150731113549
DOI https://dx.doi.org/10.2174/138955751512150731113549 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
N-acetylcysteine Versus Placebo for Treating Nail Biting, a Double Blind Randomized Placebo Controlled Clinical Trial
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Histamine H3 Receptor Ligands in the Group of (Homo)piperazine Derivatives
Current Medicinal Chemistry Investigation of the Metabolism of Rufinamide and Its Interaction with Valproate
Drug Metabolism Letters Pharmacokinetics of Topical Ocular Drug Delivery: Potential Uses for the Treatment of Diseases of the Posterior Segment and Beyond
Current Drug Metabolism The Effect of Mianserin on Lifespan of <i>Caenorhabditis elegan</i> is Abolished by Glucose
Current Aging Science Pharmacological Modulation of the State of Awareness in Patients with Disorders of Consciousness: An Overview
Current Pharmaceutical Design Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects
Current Alzheimer Research Neuropsychiatric Disturbances in Alzheimer’s Disease: What Have We Learned from Neuropathological Studies?
Current Alzheimer Research The Canonical Wnt Signaling Pathway in Autism
CNS & Neurological Disorders - Drug Targets GABAergic Drugs for the Treatment of Migraine
CNS & Neurological Disorders - Drug Targets Therapeutic Drug Monitoring of Phenytoin by Simple, Rapid, Accurate, Highly Sensitive and Novel Method and Its Clinical Applications
Current Pharmaceutical Biotechnology The NMDA Receptor NR2B Subunit: A Valid Therapeutic Target for Multiple CNS Pathologies
Current Medicinal Chemistry Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders
Current Molecular Medicine Adeno-Associated Virus Vectors: Immunobiology and Potential Use for Immune Modulation
Current Gene Therapy Proceedings of the Regional Conference of the International Society for Adolescent Psychiatry and Psychology (ISAPP), a Joint Conference with 18<sup>th</sup> National Symposium of Adolescent Mental Health, Ankara, Turkey, November 21-24, 2013<sup>1</sup>
Adolescent Psychiatry Targeting Cytokines for Morphine Tolerance: A Narrative Review
Current Neuropharmacology Patent Selections
Recent Patents on CNS Drug Discovery (Discontinued) Timing is Everything
Current Neurovascular Research Functional Interference of Dexamethasone on Some Morphine Effects:Hypothesis for the Steroid-Opioid Interaction
Recent Patents on CNS Drug Discovery (Discontinued) Anticonvulsant Sulfonamides/Sulfamates/Sulfamides with Carbonic Anhydrase Inhibitory Activity: Drug Design and Mechanism of Action
Current Pharmaceutical Design