Abstract
P38 kinase has been known to be one of the important and validated targets for inflammatory diseases including rheumatoid arthritis for its vital role in production and release of proinflammatory cytokines including tumor necrosis factor alpha (TNF-α) and interleukin-beta (IL-1β). Pyridinyl group of our reported compounds was replaced by simple phenyl groups and compounds were synthesized and characterized. A dose of 50 mg/Kg has been administered and observed antiinflammatory activity in rats. Compounds 6h, 6i, 6j and 6o exhibited significant antiinflammatory activity at 3rd hour of carrageenan administration. Compounds 6c, 6j, 6k and others demonstrated greater than 50% p38 kinase inhibitory activity at 10 μM.
Keywords: Anti-inflammatory, diphenyl urea, p38 kinase, synthesis/in vitro/in vivo.
Graphical Abstract
Related Books
Aromatherapy: The Science of Essential Oils
In Vitro Propagation and Secondary Metabolite Production from Medicinal Plants: Current Trends (Part 2)
Micropropagation of Medicinal Plants
Software and Programming Tools in Pharmaceutical Research
Biotechnology and Drug Development for Targeting Human Diseases
In Vitro Propagation and Secondary Metabolite Production from Medicinal Plants: Current Trends (Part 1)
Molecular and Physiological Insights into Plant Stress Tolerance and Applications in Agriculture- Part 2
Micropropagation of Medicinal Plants
Genome Editing in Bacteria (Part 1)
Data Science for Agricultural Innovation and Productivity
43
1
1