Abstract
Recent studies have shown that there is an interaction between fat and bone metabolisms. Adipose tissue secretes leptin and adiponectin to regulate bone metabolism. Leptin inhibits bone formation by activating the sympathetic nervous system, whereas the peripheral pathway of leptin shows a positive effect on bone formation. Opposite to leptin, adiponectin enhances or inhibits bone formation osteoblast in the central or peripheral respectively. On the other hand, osteocalcin (OCN) is decarboxylated and released from skeleton as the hormonal form of undercarboxylated-osteocalcin (ucOCN) to stimulate islets and fat to secret insulin and adiponectin respectively, thus to regulate energy metabolism. All these data indicate that there exist complex regulatory loops within fat and bone endocrine networks. In this review, we will elucidate the hormones and their receptors that mediate the communication between fat and bone metabolisms.
Keywords: Adiponectin, bone metabolism, fat metabolism, leptin, osteocalcin.
Current Signal Transduction Therapy
Title:Hormones and their Receptors Bridge Fat and Bone Metabolisms
Volume: 10 Issue: 1
Author(s): Chunyu Wang, Li Tian and Xijie Yu
Affiliation:
Keywords: Adiponectin, bone metabolism, fat metabolism, leptin, osteocalcin.
Abstract: Recent studies have shown that there is an interaction between fat and bone metabolisms. Adipose tissue secretes leptin and adiponectin to regulate bone metabolism. Leptin inhibits bone formation by activating the sympathetic nervous system, whereas the peripheral pathway of leptin shows a positive effect on bone formation. Opposite to leptin, adiponectin enhances or inhibits bone formation osteoblast in the central or peripheral respectively. On the other hand, osteocalcin (OCN) is decarboxylated and released from skeleton as the hormonal form of undercarboxylated-osteocalcin (ucOCN) to stimulate islets and fat to secret insulin and adiponectin respectively, thus to regulate energy metabolism. All these data indicate that there exist complex regulatory loops within fat and bone endocrine networks. In this review, we will elucidate the hormones and their receptors that mediate the communication between fat and bone metabolisms.
Export Options
About this article
Cite this article as:
Wang Chunyu, Tian Li and Yu Xijie, Hormones and their Receptors Bridge Fat and Bone Metabolisms, Current Signal Transduction Therapy 2015; 10 (1) . https://dx.doi.org/10.2174/157436241001150728124635
DOI https://dx.doi.org/10.2174/157436241001150728124635 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Effects of Insulin and Insulin-Like Growth Factors on Tumor Vascularization: New Insights of Insulin-Like Growth Factor Family in Cancer
Current Medicinal Chemistry Sympathetic Mechanisms of Hypoglycemic Counterregulation
Current Diabetes Reviews Oxidative Stress: Meeting Multiple Targets in Pathogenesis of Diabetic Nephropathy
Current Drug Targets Stem Cell Therapies
Recent Patents on Regenerative Medicine Aliphatic and Aromatic Oxidations, Epoxidation and S-Oxidation of Prodrugs that Yield Active Drug Metabolites
Current Medicinal Chemistry Cerebral Amyloid Angiopathy-related Intracerebral Hemorrhage Score For Predicting Outcome
Current Neurovascular Research Non-Invasive Diagnostic Tools for Investigating Endothelial Dysfunction
Current Pharmaceutical Design Synthesis, Characterization, Biological Evaluation and Docking of Coumarin Coupled Thiazolidinedione Derivatives and its Bioisosteres as PPARγ Agonists
Medicinal Chemistry Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections
Current Topics in Medicinal Chemistry Metabolomics of Serum Peptides
Protein & Peptide Letters Potential Application of Centrifuges to Protect the CNS in Space and on Earth
Current Alzheimer Research Failure of Immune Homeostasis - The Consequences of Under and Over Reactivity
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Curcumin, an Active Constiuent of the Ancient Medicinal Herb Curcuma longa L.: Some Uses and the Establishment and Biological Basis of Medical Efficacy
CNS & Neurological Disorders - Drug Targets Metabotropic Glutamate Receptors and Interacting Proteins: Evolving Drug Targets
Current Drug Targets Prolylcarboxypeptidase Gene Expression in the Heart and Kidney: Effects of Obesity and Diabetes
Cardiovascular & Hematological Agents in Medicinal Chemistry The Impact of Infection on the Incidence of Autoimmune Disease
Current Topics in Medicinal Chemistry The Effect of Stem Cell Transplantation Therapy for Post Viral Chronic Liver Cell Failure on Associated Type II Diabetes Mellitus: A Pilot Study
Endocrine, Metabolic & Immune Disorders - Drug Targets Thiazolidinediones and Cardiovascular Risk — A Question of Balance
Current Cardiology Reviews Effects of Carotenoids on Health: Are All the Same? Results from Clinical Trials
Current Pharmaceutical Design The Role of the Cytochrome P450 Polymorphisms in Clopidogrel Efficacy and Clinical Utility
Current Medicinal Chemistry