Abstract
Gout is the most common auto-inflammatory arthritis that leads to severe comorbidities such as cardiovascular diseases, renal impairment and metabolic disorders at an early age. We hypothesize that chronic as well as frequent flares of intermittent inflammation, caused by uric acid contribute to an early onset of cardiovascular-, renal- and metabolic diseases. Persistent exposure of the cells to such inflammatory events elaborates DNA damage, excessive cell turnover inconsistent with age and telomere shortening which is representative for accelerated senescence. In this review we aim to untangle the intriguing effect of inflammation-induced cellular senescence on the high prevalence of age-related cardiovascular, renal and metabolic diseases in gout.
Keywords: Gout, hyperuricemia, inflammation, DNA damage, telomere shortening, senescence, inflamm-ageing, cardiovascular diseases, renal impairment, metabolic diseases.
Current Aging Science
Title:Inflamm-ageing and senescence in gout: the tale of an old king’s disease.
Volume: 8 Issue: 2
Author(s): Nadia Vazirpanah, Timothy R.D.J. Radstake and Jasper C.A. Broen
Affiliation:
Keywords: Gout, hyperuricemia, inflammation, DNA damage, telomere shortening, senescence, inflamm-ageing, cardiovascular diseases, renal impairment, metabolic diseases.
Abstract: Gout is the most common auto-inflammatory arthritis that leads to severe comorbidities such as cardiovascular diseases, renal impairment and metabolic disorders at an early age. We hypothesize that chronic as well as frequent flares of intermittent inflammation, caused by uric acid contribute to an early onset of cardiovascular-, renal- and metabolic diseases. Persistent exposure of the cells to such inflammatory events elaborates DNA damage, excessive cell turnover inconsistent with age and telomere shortening which is representative for accelerated senescence. In this review we aim to untangle the intriguing effect of inflammation-induced cellular senescence on the high prevalence of age-related cardiovascular, renal and metabolic diseases in gout.
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Cite this article as:
Vazirpanah Nadia, Radstake R.D.J. Timothy and Broen C.A. Jasper, Inflamm-ageing and senescence in gout: the tale of an old king’s disease., Current Aging Science 2015; 8 (2) . https://dx.doi.org/10.2174/1874609808666150727112434
DOI https://dx.doi.org/10.2174/1874609808666150727112434 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
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