Abstract
The aim of this review is to provide a summary of the use of copper-catalyzed azide-alkyne cycloaddition (CuAAC) in the synthesis of porphyrin, chlorin and phthalocyanine derivatives for different types of therapeutic applications. The click reaction is a powerful and versatile tool for scientists working on the synthesis of various symmetrically and asymmetrically substituted tetrapyrrolic derivatives. For example, click chemistry is widely used for the elaboration of photosensitizer conjugates for photodynamic therapy applications. Other biological applications are also described.
Keywords: Click chemistry, Huisgen's cycloaddition, photodynamic therapy, photosensitizers, therapeutic.
Current Medicinal Chemistry
Title:Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry
Volume: 22 Issue: 28
Author(s): Samir Acherar, Ludovic Colombeau, Celine Frochot and Regis Vanderesse
Affiliation:
Keywords: Click chemistry, Huisgen's cycloaddition, photodynamic therapy, photosensitizers, therapeutic.
Abstract: The aim of this review is to provide a summary of the use of copper-catalyzed azide-alkyne cycloaddition (CuAAC) in the synthesis of porphyrin, chlorin and phthalocyanine derivatives for different types of therapeutic applications. The click reaction is a powerful and versatile tool for scientists working on the synthesis of various symmetrically and asymmetrically substituted tetrapyrrolic derivatives. For example, click chemistry is widely used for the elaboration of photosensitizer conjugates for photodynamic therapy applications. Other biological applications are also described.
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Cite this article as:
Acherar Samir, Colombeau Ludovic, Frochot Celine and Vanderesse Regis, Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry, Current Medicinal Chemistry 2015; 22 (28) . https://dx.doi.org/10.2174/0929867322666150716115832
DOI https://dx.doi.org/10.2174/0929867322666150716115832 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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