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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi

Author(s): Salvatore Genovese, Serena Fiorito, Francesco Epifano and Vito Alessandro Taddeo

Volume 22, Issue 30, 2015

Page: [3426 - 3433] Pages: 8

DOI: 10.2174/0929867322666150716114758

Price: $65

Abstract

O-Prenyl secondary metabolites (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural products. In the last two decades such compounds have been found to exert promising and effective pharmacological activities, mainly in terms of anti-cancer properties. To date about 350 oxyprenylated secondary metabolites, the most part of which having a phenylpropanoid or a polyketide core, have been extracted from plants mainly belonging to the Rutaceae, Apiaceae, and Fabaceae families, and from fungi and bacteria. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about O-prenyl secondary metabolites exhibiting in vitro and in vivo anti-cancer properties from phytochemical and pharmacological point of views.

Keywords: Anthraquinones, cancer, chalcones, cinnamic acids, coumarins, diketopiperazines, oxyprenylated secondary metabolites.


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