Abstract
Loranthus micranthus, a parasitic plant of different hosts has been used for treating various diseases traditionally as it has pharmaceutically important phytochemicals. The methanol extract of L. micranthus two fractions (17 and 21) were selected based on visibility and less compounds in TLC for identification of phytochemicals in GC-MS and yielded 13 and 12 different chemical compounds respectively. The yielded compounds from each fraction have pharmaceutical importance and possess different biological activities. Each compound’s mass spectrum was given and analysed. The two fractions were evaluated for biological activities to know the efficacy of the compounds. In both, antioxidant activities (DPPH and FRAP), the fraction 17 had shown strong activity (74, 819.48± 0.05) compared to fraction 21 and standard. The albumin denaturation, membrane stabilization and proteinase activities were tested using these two fractions and fraction 17 exhibited strong activity on these tests effectively (87.39± 0.26, 81.67± 0.23 and 86.19± 0.25). The antilipoxygenase activity (63) of fraction 17 is near to standard. Fraction 17 strongly inhibited COX-1 and COX-2 activity. Based on the results, fraction 17 had 13 different phytochemicals and exhibited strong antioxidant, anti-inflammatory and COX-1 and COX-2 activity, which may be due to a combination of all compounds or any one single compound. It can be concluded that the fractions of methanol extract of Loranthus micranthus have pharmaceutically important compound(s) and further research is needed to isolate each compound to know the exact pharmaceutical compound.
Keywords: Anti-inflammatory, antioxidant, biological activity, GC-MS, Loranthus micranthus, phytochemicals.
The Natural Products Journal
Title:Determination of Phytochemicals by GC-MS in Two Fractions (17 and 21) of Methanol Extract of Loranthus Micranthus and their Antioxidant and Anti-Inflammatory Activity
Volume: 5 Issue: 3
Author(s): Channabasava, Govindappa Melappa and Chandrashekhar Naik
Affiliation:
Keywords: Anti-inflammatory, antioxidant, biological activity, GC-MS, Loranthus micranthus, phytochemicals.
Abstract: Loranthus micranthus, a parasitic plant of different hosts has been used for treating various diseases traditionally as it has pharmaceutically important phytochemicals. The methanol extract of L. micranthus two fractions (17 and 21) were selected based on visibility and less compounds in TLC for identification of phytochemicals in GC-MS and yielded 13 and 12 different chemical compounds respectively. The yielded compounds from each fraction have pharmaceutical importance and possess different biological activities. Each compound’s mass spectrum was given and analysed. The two fractions were evaluated for biological activities to know the efficacy of the compounds. In both, antioxidant activities (DPPH and FRAP), the fraction 17 had shown strong activity (74, 819.48± 0.05) compared to fraction 21 and standard. The albumin denaturation, membrane stabilization and proteinase activities were tested using these two fractions and fraction 17 exhibited strong activity on these tests effectively (87.39± 0.26, 81.67± 0.23 and 86.19± 0.25). The antilipoxygenase activity (63) of fraction 17 is near to standard. Fraction 17 strongly inhibited COX-1 and COX-2 activity. Based on the results, fraction 17 had 13 different phytochemicals and exhibited strong antioxidant, anti-inflammatory and COX-1 and COX-2 activity, which may be due to a combination of all compounds or any one single compound. It can be concluded that the fractions of methanol extract of Loranthus micranthus have pharmaceutically important compound(s) and further research is needed to isolate each compound to know the exact pharmaceutical compound.
Export Options
About this article
Cite this article as:
Channabasava , Melappa Govindappa and Naik Chandrashekhar, Determination of Phytochemicals by GC-MS in Two Fractions (17 and 21) of Methanol Extract of Loranthus Micranthus and their Antioxidant and Anti-Inflammatory Activity, The Natural Products Journal 2015; 5 (3) . https://dx.doi.org/10.2174/2210315505666150714183424
DOI https://dx.doi.org/10.2174/2210315505666150714183424 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Serum Interleukin-33 is a Predictor of Depression in Patients with Acute Ischemic Stroke
Current Neurovascular Research Factors Affecting 30-Day Mortality in Chinese Patients with Acute Myocardial Infarction: A Registry-Based Cohort Study
Vascular Disease Prevention (Discontinued) Mechanisms Involved in Metformin Action in the Treatment of Polycystic Ovary Syndrome
Current Pharmaceutical Design Immune-Mediated Mechanisms in Atherosclerosis: Prevention and Treatment of Clinical Manifestations
Current Pharmaceutical Design New Aspects of Statin Safety
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Cardiac Oxidative Stress and Inflammatory Cytokines Response after Myocardial Infarction
Current Vascular Pharmacology Carbon Nanotube-Based Electrochemical Biosensing Platforms: Fundamentals,Applications, and Future Possibilities
Recent Patents on Biotechnology Clozapine Safety, 35 Years Later
Current Drug Safety Meet Our Section Editor
Current Vascular Pharmacology Are Circulating Monocytes as Microglia Orthologues Appropriate Biomarker Targets for Neuronal Diseases? (Supplementry Table)
Central Nervous System Agents in Medicinal Chemistry Medicinal Agents and Metabolic Syndrome
Current Medicinal Chemistry The Use of Infliximab in Dermatology
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Type 2 Diabetes and Risk for Functional Decline and Disability in Older Persons
Current Diabetes Reviews Perioperative Considerations in Rheumatoid Arthritis Patients
Current Rheumatology Reviews High-Density Lipoprotein-Mediated Anti-Atherosclerotic and Endothelial-Protective Effects: A Potential Novel Therapeutic Target in Cardiovascular Disease
Current Pharmaceutical Design Flavonoids and Chagas' Disease: The Story So Far!
Current Topics in Medicinal Chemistry An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities
Mini-Reviews in Medicinal Chemistry Realizing the Potential of Health-Promoting Rosehips from Dogroses (Rosa sect. Caninae)
Current Bioactive Compounds A Hybrid Evolutionary System for Automated Artificial Neural Networks Generation and Simplification in Biomedical Applications
Current Bioinformatics The Anti Inflammatory Effects of High Density Lipoproteins
Current Medicinal Chemistry