Abstract
Diabetes, both type 1 and type 2, is considered a chronic incurable disease. Complete cure would bring enormous benefits in terms of both the prevention of complications and reduction of the very high resulting social cost. Recent advances in the study of autoimmune mechanisms for type 1 and some non-medical therapeutic approaches for type 2 shed light on the pathophysiology and induce optimism concerning a possible cure in the not-too-distant future. This perspective highlights the main mechanisms involved in the pathophysiology of the two forms of diabetes, as the latest research has revealed, and the resulting possible therapeutic strategies that may be involved in obtaining a cure.
Keywords: Bariatric/metabolic surgery, gut-brain-liver/pancreas axis, neonatal transitory diabetes, oropharyngeal radiating therapy, T regulatory cells, type 1 diabetes pathophysiology, type 2 diabetes pathophysiology, vagal brainstem circuits.
Current Diabetes Reviews
Title:Can Diabetes Heal?- From Observations to Perspectives
Volume: 12 Issue: 3
Author(s): Claudio Blasi
Affiliation:
Keywords: Bariatric/metabolic surgery, gut-brain-liver/pancreas axis, neonatal transitory diabetes, oropharyngeal radiating therapy, T regulatory cells, type 1 diabetes pathophysiology, type 2 diabetes pathophysiology, vagal brainstem circuits.
Abstract: Diabetes, both type 1 and type 2, is considered a chronic incurable disease. Complete cure would bring enormous benefits in terms of both the prevention of complications and reduction of the very high resulting social cost. Recent advances in the study of autoimmune mechanisms for type 1 and some non-medical therapeutic approaches for type 2 shed light on the pathophysiology and induce optimism concerning a possible cure in the not-too-distant future. This perspective highlights the main mechanisms involved in the pathophysiology of the two forms of diabetes, as the latest research has revealed, and the resulting possible therapeutic strategies that may be involved in obtaining a cure.
Export Options
About this article
Cite this article as:
Blasi Claudio, Can Diabetes Heal?- From Observations to Perspectives, Current Diabetes Reviews 2016; 12 (3) . https://dx.doi.org/10.2174/1573399811666150702125702
DOI https://dx.doi.org/10.2174/1573399811666150702125702 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nanomaterials in the Pharmaceuticals: Occurrence, Behaviour and Applications
Current Pharmaceutical Design HPV Infection and Intraepithelial Lesions: Comparison Between HIVPositive and Negative Women
Current HIV Research Recent Advances in Receptor-Targeted Fluorescent Probes for In Vivo Cancer Imaging
Current Medicinal Chemistry Concomitant CXCR4 and CXCR7 Expression Predicts Poor Prognosis in Renal Cancer
Current Cancer Drug Targets DLEU1: A Functional Long Noncoding RNA in Tumorigenesis
Current Pharmaceutical Design Adhesion Dependent Signalling in the Tumour Microenvironment: The Future of Drug Targetting
Current Pharmaceutical Design Lipoxygenase (LOX) Pathway: A Promising Target to Combat Cancer
Current Pharmaceutical Design Medical Treatment of Malignancy-Associated Hypercalcemia
Current Medicinal Chemistry Viral Based Gene Therapy for Prostate Cancer
Current Gene Therapy Targeting HOTAIR induces mitochondria related apoptosis and inhibits tumor growth in head and neck squamous cell carcinoma in vitro and in vivo.
Current Molecular Medicine Piperidin-4-one: The Potential Pharmacophore
Mini-Reviews in Medicinal Chemistry Hepatocyte Growth Factor and Macrophage-stimulating Protein “Hinge” Analogs to Treat Pancreatic Cancer
Current Cancer Drug Targets HtrA Protease Family as Therapeutic Targets
Current Pharmaceutical Design The Relationship Between Oncogene Expression and Clinical Outcome in Endometrial Carcinoma
Current Cancer Drug Targets The Proteins Interacting with Prmt5 in Medaka (Oryzias latipes) Identified by Yeast Two-Hybridization
Protein & Peptide Letters Cell Hierarchy, Metabolic Flexibility and Systems Approaches to Cancer Treatment
Current Pharmaceutical Biotechnology <i>Circular RNA NF1-419</i> Inhibits Proliferation and Induces Apoptosis by Regulating Lipid Metabolism in Astroglioma Cells
Recent Patents on Anti-Cancer Drug Discovery Radiosensitizing Potential of Epigenetic Anticancer Drugs
Anti-Cancer Agents in Medicinal Chemistry Unknown Primary Squamous Cell Carcinoma of the Head and Neck
Current Cancer Therapy Reviews FDG-PET/CT Predicts Outcome in Oropharingeal Carcinoma Patients Undergoing Intensity Modulated Radiation Therapy with Dose Escalation to FDG-avid Tumour Volumes
Current Radiopharmaceuticals