Abstract
Diversity oriented, efficient and environmentally benign synthetic protocol has been presented for the synthesis of spiroquinazolinones. The hybrid drug-like small molecules incorporating medicinally privileged heterocyclic systems have been synthesized by tandem reaction of 3-aminocrotonnitrile, phenyl hydrazine/ hydrazine hydrate, isatoic anhydride and isatin using deep eutectic solvent as efficient catalyst and environmentally benign reaction medium.
Keywords: Deep eutectic solvent, HBD (Hydrogen bond donor), Ionic liquid, Tandem reaction, Privileged heterocyclic structure, Spiroquinazolinone.
Current Organic Synthesis
Title:Environmentally Benign Synthetic Protocol for the Synthesis of Spiroquinazolinones Using Sustainable and Recyclable Choline Chloride Based Deep Eutectic Mixture
Volume: 12 Issue: 4
Author(s): Yogesh Kumar Tailor, Sarita Khandelwal, Hemant Kumar Jain and Mahendra Kumar
Affiliation:
Keywords: Deep eutectic solvent, HBD (Hydrogen bond donor), Ionic liquid, Tandem reaction, Privileged heterocyclic structure, Spiroquinazolinone.
Abstract: Diversity oriented, efficient and environmentally benign synthetic protocol has been presented for the synthesis of spiroquinazolinones. The hybrid drug-like small molecules incorporating medicinally privileged heterocyclic systems have been synthesized by tandem reaction of 3-aminocrotonnitrile, phenyl hydrazine/ hydrazine hydrate, isatoic anhydride and isatin using deep eutectic solvent as efficient catalyst and environmentally benign reaction medium.
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Cite this article as:
Kumar Tailor Yogesh, Khandelwal Sarita, Kumar Jain Hemant and Kumar Mahendra, Environmentally Benign Synthetic Protocol for the Synthesis of Spiroquinazolinones Using Sustainable and Recyclable Choline Chloride Based Deep Eutectic Mixture, Current Organic Synthesis 2015; 12 (4) . https://dx.doi.org/10.2174/157017941204150522190425
DOI https://dx.doi.org/10.2174/157017941204150522190425 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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