Abstract
An efficient and environmentally benign diversity oriented synthetic protocol has been presented for the synthesis of structurally diverse spiroquinazolines. The hybrid druglike molecules incorporating medicinally privileged heterocyclic systems (spiroquinazolinespirooxindoles) have been synthesized by three-component reaction of isatoic anhydride, aromatic amines and substituted isatins using gluconic acid aqueous solution (GAAS, 50%, wt%) as an efficient, inexpensive and eco-friendly bio-based catalytic solvent system.
Keywords: Diversity oriented synthesis, environmentally benign synthetic protocol, spiroquinazoline-spirooxindoles, gluconic acid aqueous solution (GAAS, 50%, wt%).
Current Catalysis
Title:An Efficient and Environmentally Benign One-pot Three- Component Domino Protocol for the Synthesis of Structurally Diverse Spiroquinazolines
Volume: 4 Issue: 3
Author(s): Sarita Khandelwal, Anshu Rajawat and Mahendra Kumar
Affiliation:
Keywords: Diversity oriented synthesis, environmentally benign synthetic protocol, spiroquinazoline-spirooxindoles, gluconic acid aqueous solution (GAAS, 50%, wt%).
Abstract: An efficient and environmentally benign diversity oriented synthetic protocol has been presented for the synthesis of structurally diverse spiroquinazolines. The hybrid druglike molecules incorporating medicinally privileged heterocyclic systems (spiroquinazolinespirooxindoles) have been synthesized by three-component reaction of isatoic anhydride, aromatic amines and substituted isatins using gluconic acid aqueous solution (GAAS, 50%, wt%) as an efficient, inexpensive and eco-friendly bio-based catalytic solvent system.
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Cite this article as:
Khandelwal Sarita, Rajawat Anshu and Kumar Mahendra, An Efficient and Environmentally Benign One-pot Three- Component Domino Protocol for the Synthesis of Structurally Diverse Spiroquinazolines, Current Catalysis 2015; 4 (3) . https://dx.doi.org/10.2174/2211544704666150508221522
DOI https://dx.doi.org/10.2174/2211544704666150508221522 |
Print ISSN 2211-5447 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5455 |
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