Abstract
Living systems have evolved a variety of complex nanostructures to control biomolecular interactions and biochemical reactions that are vital to the metabolism and reproduction. During the past few decades, single-molecule detection and imaging have been widely applied to interpreting biological processes in detail, which are able to observe the chemical reactions and kinetic behaviors of individual molecules. The rapid development of structural DNA nanotechnology has provided adaptable platforms to facilitate single-molecule detection and super-resolution imaging of individual biological components, as well as manipulating artificial nanosystems with molecular precision. In this review, we summarize recent exciting progress in using DNA nanostructures to sense and manipulate biomolecular interactions at the single-molecule level.
Keywords: AFM label-free detection, DNA nanostructures, nanorobots, single-molecule detection, super-resolution fluorescence imaging.
Current Nanoscience
Title:Single-Molecule Sensing of Biomolecular Interactions on DNA Nanostructures
Volume: 11 Issue: 6
Author(s): Ting Zhang, John Collins and Jinglin Fu
Affiliation:
Keywords: AFM label-free detection, DNA nanostructures, nanorobots, single-molecule detection, super-resolution fluorescence imaging.
Abstract: Living systems have evolved a variety of complex nanostructures to control biomolecular interactions and biochemical reactions that are vital to the metabolism and reproduction. During the past few decades, single-molecule detection and imaging have been widely applied to interpreting biological processes in detail, which are able to observe the chemical reactions and kinetic behaviors of individual molecules. The rapid development of structural DNA nanotechnology has provided adaptable platforms to facilitate single-molecule detection and super-resolution imaging of individual biological components, as well as manipulating artificial nanosystems with molecular precision. In this review, we summarize recent exciting progress in using DNA nanostructures to sense and manipulate biomolecular interactions at the single-molecule level.
Export Options
About this article
Cite this article as:
Zhang Ting, Collins John and Fu Jinglin, Single-Molecule Sensing of Biomolecular Interactions on DNA Nanostructures, Current Nanoscience 2015; 11 (6) . https://dx.doi.org/10.2174/1573413711666150505223339
DOI https://dx.doi.org/10.2174/1573413711666150505223339 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cell-Based Biosensors in Clinical Chemistry
Mini-Reviews in Medicinal Chemistry Cyclodextrin-based Materials for Removing Micropollutants From Wastewater
Current Organic Chemistry Mixed Lineage Kinase Family, Potential Targets for Preventing Neurodegeneration
Current Medicinal Chemistry - Central Nervous System Agents Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver
Current Drug Metabolism Introduction to the Chirality of Resorcinarenes
Mini-Reviews in Organic Chemistry Optimization and Analysis of Acid Treated Trimethylamine using Surface Response and Gas Chromatography Analytical Methods
Current Analytical Chemistry Novel Therapeutic Strategies for Dementia
CNS & Neurological Disorders - Drug Targets Recent Advances in the Chemistry and Synthesis of Thienopyrazine, Pyrrolopyrazine and Furopyrazine Derivatives
Current Organic Chemistry Novel Drug Targets in Malaria Parasite with Potential to Yield Antimalarial Drugs with Long Useful Therapeutic Lives
Current Pharmaceutical Design Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L.
Current Bioactive Compounds Resveratrol Improves Cardiovascular Function in DOCA-Salt Hypertensive Rats
Current Pharmaceutical Biotechnology A Cross Sectional Study of Tumors Using Bio-Medical Imaging Modalities
Current Medical Imaging Nanoparticulate Drug Delivery to Colorectal Cancer: Formulation Strategies and Surface Engineering
Current Pharmaceutical Design Acethylcholinesterase Inhibition, Antibacterial and Antioxidant Properties of Diaryl Oxalates
Current Enzyme Inhibition The Anti-Breast Cancer Effects of Green-Synthesized Zinc Oxide Nanoparticles Using Carob Extracts
Anti-Cancer Agents in Medicinal Chemistry Aptamers as Therapeutics in Cardiovascular Diseases
Current Medicinal Chemistry Recent Advances and Approaches in Targeting Apoptosis Signaling Pathways for Anti-Cancer Therapeutics
Current Cancer Therapy Reviews Cigarette Smoking and Angiogenesis: What is the Role of Endothelial Progenitor Cells?
Current Angiogenesis (Discontinued) Structure-Activity Relationship of Supramolecular Compounds in Drug Delivery
Mini-Reviews in Organic Chemistry CASC15: A Tumor-Associated Long Non-Coding RNA
Current Pharmaceutical Design