Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3- Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3- Carboxylates and their In-Silico Evaluation Against P. falciparum Lactate Dehydrogenase

Title:Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3- Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3- Carboxylates and their In-Silico Evaluation Against P. falciparum Lactate Dehydrogenase

Volume: 11 Issue: 8

Author(s): Kancherla Rajesh, Pandian Lavanya, Pethaperumal Iniyavan, Sundaramoorthy Sarveswari, Sudha Ramaiah, Anand Anbarasu and Vijayaparthasarathi Vijayakumar

Affiliation:

Keywords: Polyhydroquinoline, 2, 4-Dichloroquinolines, regioselectivity, in-silico analysis, P. falciparum lactate dehydrogenase.

Abstract: The reaction of various substituted 2, 4-dichloroquinolines with ethyl 4-(3-hydroxyphenyl)- 2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was carried out in the presence of K₂CO₃ as a mild and efficient base at controlled temperature leading to novel 2-chloroquinoline based polyhydroquinoline with high regioselectivity. All the synthesized compounds were characterized using IR, NMR, Mass spectral data and then subjected to an in-silico analysis against P. falciparum lactate dehydrogenase.

Cite this article as:

Rajesh Kancherla, Lavanya Pandian, Iniyavan Pethaperumal, Sarveswari Sundaramoorthy, Ramaiah Sudha, Anbarasu Anand and Vijayakumar Vijayaparthasarathi, Regioselective Synthesis of 2-Chloroquinoline Based Ethyl 4-(3- Hydroxyphenyl)-2,7,7-Trimethyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline-3- Carboxylates and their In-Silico Evaluation Against P. falciparum Lactate Dehydrogenase, Medicinal Chemistry 2015; 11 (8) . https://dx.doi.org/10.2174/1573406411666150430132055