Abstract
Thromboangiitis obliterans (TAO) is a thrombotic-occlusive and an inflammatory peripheral arterial disease with unidentified aetiology. Thrombotic events can lead to limb loss in TAO patients, who are typically young male smokers of low socioeconomic status. It is still unknown whether the initial process is thrombosis or inflammation, so it is difficult to ascertain whether managing inflammation or thrombosis improves the outcome of the disease. In this review, the possible mechanisms of thrombosis in TAO are evaluated; the treatments, based on the discussed mechanisms of thrombosis in TAO, are then reviewed and the challenges and limitations associated with the management of TAO are discussed.
Keywords: Buerger’s disease, Nitric oxide, Thromboangiitis obliterans, Thrombolysis, Thrombosis, Treatment.
Current Medicinal Chemistry
Title:Mechanisms of Thrombosis, Available Treatments and Management Challenges Presented by Thromboangiitis Obliterans
Volume: 22 Issue: 16
Author(s): Bahare Fazeli and Hassan Ravari
Affiliation:
Keywords: Buerger’s disease, Nitric oxide, Thromboangiitis obliterans, Thrombolysis, Thrombosis, Treatment.
Abstract: Thromboangiitis obliterans (TAO) is a thrombotic-occlusive and an inflammatory peripheral arterial disease with unidentified aetiology. Thrombotic events can lead to limb loss in TAO patients, who are typically young male smokers of low socioeconomic status. It is still unknown whether the initial process is thrombosis or inflammation, so it is difficult to ascertain whether managing inflammation or thrombosis improves the outcome of the disease. In this review, the possible mechanisms of thrombosis in TAO are evaluated; the treatments, based on the discussed mechanisms of thrombosis in TAO, are then reviewed and the challenges and limitations associated with the management of TAO are discussed.
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Fazeli Bahare and Ravari Hassan, Mechanisms of Thrombosis, Available Treatments and Management Challenges Presented by Thromboangiitis Obliterans, Current Medicinal Chemistry 2015; 22 (16) . https://dx.doi.org/10.2174/0929867322666150429112111
DOI https://dx.doi.org/10.2174/0929867322666150429112111 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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