Abstract
Anxiety is one of the behavior disorders that has been studied more together with depression in the world, and that has enormous interference in the mental health of the affected patients. The states of panic and phobia are a part of the psychological characteristics that some drugs have tried to control though with varied side effects that are proven to be difficult to control. The use of perimidinone derivatives against the effects of anxiety has generated that A5 is the most active and selective anxiolytic compound, differing with regard to diazepam (DZP) used as control reference in elevated plus-maze (EPM) test. This test allows to conclude that it is feasible to differentiate the use selective as anxiolytic or antidepressant of certain perimidinones, because A4 had been characterized by our research group as an important antidepressant respect to A5 studied in previous reports.
Keywords: 7H-benzo[e]perimidin-7-one, Anxiety, Depression, Oxoisoaporphines, Perimidinones, Plus-maze test.
Current Topics in Medicinal Chemistry
Title:Anxiolytic-Like Effects of 7H-Benzo[e]perimidin-7-One Derivatives through Elevated Plus-Maze Test in Mice
Volume: 15 Issue: 17
Author(s): Jorge Nunez, Jose A. Fontenla, Seyed Mohammad Nabavi, Eugenio Uriarte, Alejandra Herrera and Eduardo Sobarzo-Sanchez
Affiliation:
Keywords: 7H-benzo[e]perimidin-7-one, Anxiety, Depression, Oxoisoaporphines, Perimidinones, Plus-maze test.
Abstract: Anxiety is one of the behavior disorders that has been studied more together with depression in the world, and that has enormous interference in the mental health of the affected patients. The states of panic and phobia are a part of the psychological characteristics that some drugs have tried to control though with varied side effects that are proven to be difficult to control. The use of perimidinone derivatives against the effects of anxiety has generated that A5 is the most active and selective anxiolytic compound, differing with regard to diazepam (DZP) used as control reference in elevated plus-maze (EPM) test. This test allows to conclude that it is feasible to differentiate the use selective as anxiolytic or antidepressant of certain perimidinones, because A4 had been characterized by our research group as an important antidepressant respect to A5 studied in previous reports.
Export Options
About this article
Cite this article as:
Nunez Jorge, Fontenla A. Jose, Nabavi Mohammad Seyed, Uriarte Eugenio, Herrera Alejandra and Sobarzo-Sanchez Eduardo, Anxiolytic-Like Effects of 7H-Benzo[e]perimidin-7-One Derivatives through Elevated Plus-Maze Test in Mice, Current Topics in Medicinal Chemistry 2015; 15 (17) . https://dx.doi.org/10.2174/1568026615666150427125535
DOI https://dx.doi.org/10.2174/1568026615666150427125535 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of Monocarboxylate Transporters in Drug Delivery to the Brain
Current Pharmaceutical Design Facts and Fiction: Cellular Models for High Throughput Screening for HIV-1 Reactivating Drugs
Current HIV Research The Potential Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Epilepsy Pathogenesis
Endocrine, Metabolic & Immune Disorders - Drug Targets Coenzyme Q10 in Neuromuscular and Neurodegenerative Disorders
Current Drug Targets Aliphatic and Aromatic Oxidations, Epoxidation and S-Oxidation of Prodrugs that Yield Active Drug Metabolites
Current Medicinal Chemistry Valproate and Neuroendocrine Changes in Relation to Women Treated for Epilepsy and Bipolar Disorder: A Review
Current Medicinal Chemistry A Review of Recent Patents on the ASICs as a Key Drug Target
Recent Patents on Biotechnology Small Molecule Modulation of p75 Neurotrophin Receptor Functions
CNS & Neurological Disorders - Drug Targets Antiepileptic Treatment Strategy in Vascular Malformations
Current Pharmaceutical Design Chemistry and Health Effects of Bioactive Compounds in Selected Culinary Aromatic Herbs
Current Nutrition & Food Science Recent Developments on KCNQ Potassium Channel Openers
Current Medicinal Chemistry The Role of Structure Activity Relationship Studies in the Search for New GABA Uptake Inhibitors
Mini-Reviews in Medicinal Chemistry The Role of Reactive Species in Epileptogenesis and Influence of Antiepileptic Drug Therapy on Oxidative Stress
Current Neuropharmacology The Effects of Soluble Aβ Oligomers on Neurodegeneration in Alzheimer's Disease
Current Pharmaceutical Design Pharmacological Innovations for Posttraumatic Stress Disorder and Medication- Enhanced Psychotherapy
Current Pharmaceutical Design Proteins Structures in Leishmania Amastigotes for Clinical Remission of Psoriasis
Current Proteomics Bacopa monnieri Supplements Offset Paraquat-Induced Behavioral Phenotype and Brain Oxidative Pathways in Mice
Central Nervous System Agents in Medicinal Chemistry Information of ADME-Associated Proteins and Potential Application for Pharmacogenetic Prediction of Drug Responses
Current Pharmacogenomics Application of Contemporary Neuroproteomic Techniques in Unravelling Neurological Disorders
Current Protein & Peptide Science Editorial [Is Drug Safety Dangerous?]
Current Drug Safety