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Current Organocatalysis

Editor-in-Chief

ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds

Author(s): Avik Kumar Bagdi, Dhiman Kundu, Adinath Majee and Alakananda Hajra

Volume 3, Issue 2, 2016

Page: [169 - 175] Pages: 7

DOI: 10.2174/2213337202666150414201734

Price: $65

Abstract

An efficient, simple and environmentally benign methodology has been developed for the synthesis of 5,6-unsubstituted 1,4-dihydropyridine derivatives by a three-component condensation of β-keto esters, amines and α,β-unsaturated aldehydes under solvent-free conditions catalyzed by an aprotic imidazole-based zwitterionic salt. The key advantages of this protocol are metal-free reaction conditions, short reaction time, high yields, reusability of the catalyst, and easy work-up. A variety of dihydropyridine derivatives have been synthesized with high yields at room temperature and only water is formed as a green by-product.

Keywords: Dihydropyridines, imidazolium zwitterion, multicomponent, organocatalysis, reusability, solvent-free.


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