Abstract
The use of aptamers as targeting molecules has revolutionized nanomedicine. Aptamers are short oligonucleotides or peptides that can be used as targeting ligands against numerous targets. Aptamers are versatile moieties that can be used both in therapeutic and targeting applications. Aptamers bind to the target in a process that is similar to the lock and key mechanism. There are numerous reports on the use of aptamers as targeting moieties for imaging and drug delivery applications. In this review, we would like to give a comprehensive report on aptamers, its properties and the developments in aptamer mediated drug delivery in the recent years.
Keywords: Nanomedicine, Aptamers, Targeting, Nanotherapy.
Current Topics in Medicinal Chemistry
Title:Aptamers in Targeted Nanotherapy
Volume: 15 Issue: 12
Author(s): Anila Mathew, Toru Maekawa and D. Sakthikumar
Affiliation:
Keywords: Nanomedicine, Aptamers, Targeting, Nanotherapy.
Abstract: The use of aptamers as targeting molecules has revolutionized nanomedicine. Aptamers are short oligonucleotides or peptides that can be used as targeting ligands against numerous targets. Aptamers are versatile moieties that can be used both in therapeutic and targeting applications. Aptamers bind to the target in a process that is similar to the lock and key mechanism. There are numerous reports on the use of aptamers as targeting moieties for imaging and drug delivery applications. In this review, we would like to give a comprehensive report on aptamers, its properties and the developments in aptamer mediated drug delivery in the recent years.
Export Options
About this article
Cite this article as:
Mathew Anila, Maekawa Toru and Sakthikumar D., Aptamers in Targeted Nanotherapy, Current Topics in Medicinal Chemistry 2015; 15 (12) . https://dx.doi.org/10.2174/1568026615666150413153525
DOI https://dx.doi.org/10.2174/1568026615666150413153525 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Advances in Targeting Nuclear Molecular Imaging Driven by Tetrazine Bioorthogonal Chemistry
Current Medicinal Chemistry Roles of EGFR, PI3K, AKT, and mTOR in Heavy Metal-Induced Cancer
Current Cancer Drug Targets Recent Progress in Chemically Modified siRNAs
Mini-Reviews in Medicinal Chemistry Nuclear Magnetic Resonance Spectroscopy and Genetic Disorders
Current Medicinal Chemistry Editorial (Thematic Issue: Immunophilins, Protein Chemistry and Cell Biology of a Promising New Class of Drug Targets – Part II)
Current Molecular Pharmacology Suicide Gene Therapy Mediated by the Herpes Simplex Virus Thymidine Kinase Gene / Ganciclovir System: Fifteen Years of Application
Current Gene Therapy Quantitative Proteomics for Cancer Biomarker Discovery
Combinatorial Chemistry & High Throughput Screening Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors
Current Medicinal Chemistry Gankyrin Oncoprotein: Structure, Function, and Involvement in Cancer
Current Chemical Biology Oxidative Stress, Redox Signaling and Cancer Chemoresistance: Putting Together the Pieces of the Puzzle
Current Medicinal Chemistry The Role of Phenolic Compounds in the Fight against Cancer – A Review
Anti-Cancer Agents in Medicinal Chemistry Patent Selections:
Recent Patents on CNS Drug Discovery (Discontinued) Suicide Gene Therapy Against Malignant Gliomas by the Local Delivery of Genetically Engineered Umbilical Cord Mesenchymal Stem Cells as Cellular Vehicles
Current Gene Therapy MicroRNAs: Key Players in Microglia and Astrocyte Mediated Inflammation in CNS Pathologies
Current Medicinal Chemistry Graphene and Graphene Oxide as a Docking Station for Modern Drug Delivery System
Current Drug Delivery New Platinum and Ruthenium Complexes - the Latest Class of Potential Chemotherapeutic Drugs - a Review of Recent Developments in the Field
Mini-Reviews in Medicinal Chemistry Metalloproteinases and Metalloproteinase Inhibitors in Age-Related Diseases
Current Pharmaceutical Design IL-2 Receptor Targeted Immunomodulatory Biologics: The Past, Present, and Future
Current Immunology Reviews (Discontinued) Editorial [Hot Topic:Angiogenesis Agents(Executive Editor: Cezary Marcinkiewicz)]
Current Pharmaceutical Design Himalayan Plants as a Source of Anti-Cancer Agents: A Review
The Natural Products Journal