Abstract
Leishmaniasis affects more than 12 million people in 98 countries, the infection being caused by more than 20 species of protozoan parasites belonging to the genus Leishmania and spread by sandflies bite. Poor sanitary conditions, malnutrition, deforestation and urbanization increase the risk for leishmaniasis. Leishmaniasis is the only tropical disease treated with non-anti-leishmanial drugs, among which liposomal amphotericin B, a combination of pentavalent antimonials and paromomycin and miltefosine, that are highly toxic, represent the most used ones. Drug resistance is now widespread and the search for new molecular targets is open. Topoisomerase 1B, that controls the topological state of DNA and is essential for the parasites viability, has been detected as a promising target for antileishmaniasis therapy. The enzyme presents structural/functional differences with the human counterpart, making it unique among Eukarya. Here we review the structural features of this enzyme and the drugs that can be developed and used for this specific targeting.
Keywords: Anti-leishmanial drugs, Drug development, Leishmaniasis, Parasitic infections, Protozoa, Topoisomerase 1B.
Mini-Reviews in Medicinal Chemistry
Title:Topoisomerase 1B as a Target Against Leishmaniasis
Volume: 15 Issue: 3
Author(s): Ilda D’Annessa, Silvia Castelli and Alessandro Desideri
Affiliation:
Keywords: Anti-leishmanial drugs, Drug development, Leishmaniasis, Parasitic infections, Protozoa, Topoisomerase 1B.
Abstract: Leishmaniasis affects more than 12 million people in 98 countries, the infection being caused by more than 20 species of protozoan parasites belonging to the genus Leishmania and spread by sandflies bite. Poor sanitary conditions, malnutrition, deforestation and urbanization increase the risk for leishmaniasis. Leishmaniasis is the only tropical disease treated with non-anti-leishmanial drugs, among which liposomal amphotericin B, a combination of pentavalent antimonials and paromomycin and miltefosine, that are highly toxic, represent the most used ones. Drug resistance is now widespread and the search for new molecular targets is open. Topoisomerase 1B, that controls the topological state of DNA and is essential for the parasites viability, has been detected as a promising target for antileishmaniasis therapy. The enzyme presents structural/functional differences with the human counterpart, making it unique among Eukarya. Here we review the structural features of this enzyme and the drugs that can be developed and used for this specific targeting.
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Cite this article as:
D’Annessa Ilda, Castelli Silvia and Desideri Alessandro, Topoisomerase 1B as a Target Against Leishmaniasis, Mini-Reviews in Medicinal Chemistry 2015; 15 (3) . https://dx.doi.org/10.2174/138955751503150312120912
DOI https://dx.doi.org/10.2174/138955751503150312120912 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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