Abstract
Positron emission tomography (PET) is one of the most rapidly growing areas of medical imaging for cancer research. The principal goal of PET imaging is to visualize, characterize, and measure biological processes at the molecular and cellular levels in living subjects using non-invasive procedures. Taking advantage of the traditional diagnostic imaging techniques, PET imaging introduces positron-emitting probes to determine the expression of indicative molecular targets at different stages of cancer progression. As a key component of PET technique, an appropriate imaging probe must be able to specifically reach the target of interest in vivo while retaining in the target within reasonable time to be detected. Over the last decade, numerous target-specific PET probes have been developed and evaluated in preclinical and clinical studies. This review provides an overview of recent advances made in PET imaging of cancer biology with a focus on the best-studied biological targets. The trends in developing future PET imaging probes are also discussed.
Keywords: Angiogenesis, cancer, Cell death, Cell proliferation, Hypoxia, Molecular imaging probe, Positron emission tomography (PET).
Current Topics in Medicinal Chemistry
Title:Development of PET Probes for Cancer Imaging
Volume: 15 Issue: 8
Author(s): Rui Huang, Mingwei Wang, Yizhou Zhu, Peter S. Conti and Kai Chen
Affiliation:
Keywords: Angiogenesis, cancer, Cell death, Cell proliferation, Hypoxia, Molecular imaging probe, Positron emission tomography (PET).
Abstract: Positron emission tomography (PET) is one of the most rapidly growing areas of medical imaging for cancer research. The principal goal of PET imaging is to visualize, characterize, and measure biological processes at the molecular and cellular levels in living subjects using non-invasive procedures. Taking advantage of the traditional diagnostic imaging techniques, PET imaging introduces positron-emitting probes to determine the expression of indicative molecular targets at different stages of cancer progression. As a key component of PET technique, an appropriate imaging probe must be able to specifically reach the target of interest in vivo while retaining in the target within reasonable time to be detected. Over the last decade, numerous target-specific PET probes have been developed and evaluated in preclinical and clinical studies. This review provides an overview of recent advances made in PET imaging of cancer biology with a focus on the best-studied biological targets. The trends in developing future PET imaging probes are also discussed.
Export Options
About this article
Cite this article as:
Huang Rui, Wang Mingwei, Zhu Yizhou, Conti S. Peter and Chen Kai, Development of PET Probes for Cancer Imaging, Current Topics in Medicinal Chemistry 2015; 15 (8) . https://dx.doi.org/10.2174/1568026615666150302110325
DOI https://dx.doi.org/10.2174/1568026615666150302110325 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis
Cardiovascular & Hematological Agents in Medicinal Chemistry Technologies for Translational Imaging Using Generators in Oncology
Recent Patents on Anti-Cancer Drug Discovery Role of miRNAs in Cancer Diagnostics and Therapy: A Recent Update
Current Pharmaceutical Design Serotonin and Cancer: What Is the Link?
Current Molecular Medicine Single-Photon Emission Computed Tomography Tracers for Predicting and Monitoring Cancer Therapy
Current Pharmaceutical Biotechnology [177Lu]-DOTA0-Tyr3-Octreotate: A Potential Targeted Radiotherapeutic for the Treatment of Medulloblastoma
Current Radiopharmaceuticals PET with Non-Standard Nuclides
Current Topics in Medicinal Chemistry Small Molecule Toxins Targeting Tumor Receptors
Current Pharmaceutical Design The Current Role of PET/CT in Radiotherapy Planning
Current Radiopharmaceuticals Small Peptide and Protein-based Molecular Probes for Imaging Neurological Diseases
Current Protein & Peptide Science Somatostatin and its Analogs
Current Drug Targets Adhesion Molecules in Lung Cancer: Implications in the Pathogenesis and Management
Current Pharmaceutical Design Molecular Imaging of Neuropsychiatry and Boron Neutron Capture Therapy in Neuro-oncology
Current Molecular Imaging (Discontinued) Targeting Toll-like Receptors in Autoimmunity
Current Drug Targets Clinical Development of Inhibitors of the Insulin-like Growth Factor Receptor in Oncology
Current Drug Targets Current Status and Perspectives in Peptide Receptor Radiation Therapy
Current Pharmaceutical Design MicroRNAs as Tools and Effectors for Patient Treatment in Gastrointestinal Carcinogenesis
Current Drug Targets New Medical Strategies for Midgut Carcinoids
Anti-Cancer Agents in Medicinal Chemistry Overcoming Drug Resistance by Enhancing Apoptosis of Tumor Cells
Current Cancer Drug Targets Tubulin-Targeting Agents in Hybrid Drugs
Current Medicinal Chemistry