Abstract
Induced pluripotent stem cells (iPSCs) technology provides unique possibilities for human disease modeling and novel therapeutic approach in regenerative medicine. By applying this technology, it is possible to establish highfidelity human disease models from biopsy samples of different individuals with various genetic backgrounds. This may provide a better understanding of patient-specific pathophysiological processes of a wide variety of diseases. Stem cell-derived intestinal epithelia and human intestinal organoids (HIOs) generated in vitro, for example, can faciliate drug screening and modeling of inflammation-associated gastrointestinal diseases. In this review, we highlight novel achievements of generating disease-related iPSCs and discuss their potential applications in the modeling of gastrointestinal disorders. The critical influencing factors, main limitations and possible improvements in the process of iPSCs-based disease modeling are also discussed.
Keywords: Gastroenterology, gastrointestinal diseases, iPSCs, modeling.
Current Stem Cell Research & Therapy
Title:Potential Applications of Induced Pluripotent Stem Cells (iPSCs) in the Modeling of Gastrointestinal Disorders
Volume: 10 Issue: 3
Author(s): Shu Liu, Dai Zhang, Yushuai Chen, Bingyuan Wang and Liang Qiao
Affiliation:
Keywords: Gastroenterology, gastrointestinal diseases, iPSCs, modeling.
Abstract: Induced pluripotent stem cells (iPSCs) technology provides unique possibilities for human disease modeling and novel therapeutic approach in regenerative medicine. By applying this technology, it is possible to establish highfidelity human disease models from biopsy samples of different individuals with various genetic backgrounds. This may provide a better understanding of patient-specific pathophysiological processes of a wide variety of diseases. Stem cell-derived intestinal epithelia and human intestinal organoids (HIOs) generated in vitro, for example, can faciliate drug screening and modeling of inflammation-associated gastrointestinal diseases. In this review, we highlight novel achievements of generating disease-related iPSCs and discuss their potential applications in the modeling of gastrointestinal disorders. The critical influencing factors, main limitations and possible improvements in the process of iPSCs-based disease modeling are also discussed.
Export Options
About this article
Cite this article as:
Liu Shu, Zhang Dai, Chen Yushuai, Wang Bingyuan and Qiao Liang, Potential Applications of Induced Pluripotent Stem Cells (iPSCs) in the Modeling of Gastrointestinal Disorders, Current Stem Cell Research & Therapy 2015; 10 (3) . https://dx.doi.org/10.2174/1574888X10666150227130122
DOI https://dx.doi.org/10.2174/1574888X10666150227130122 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Century of Thioxanthones: Through Synthesis and Biological Applications
Current Medicinal Chemistry Amniotic Fluid Stem Cells: a Promising Therapeutic Resource for Cell-Based Regenerative Therapy
Current Pharmaceutical Design An Overview of Highly Optically Pure Chloramphenicol Bases: Applications and Modifications
Mini-Reviews in Medicinal Chemistry Targeting Trypanosoma cruzi Platelet-activating Factor Receptors: Scope for the Development of Novel Drugs to Treat Chagas Disease
Mini-Reviews in Medicinal Chemistry Ribozymes, DNAzymes and Small Interfering RNAs as Therapeutics
Current Drug Targets Animal Models for Studying Neointima Formation
Current Vascular Pharmacology An Overview on Different Classes of Viral Entry and Respiratory Syncitial Virus (RSV) Fusion Inhibitors
Current Medicinal Chemistry Vitamin D and Cystic Fibrosis Lung Disease
Mini-Reviews in Medicinal Chemistry Cardiovascular Disease Burden and Risk Factors Before and After Kidney Transplant
Cardiovascular & Hematological Disorders-Drug Targets Viscosupplementation with Intra-Articular Hyaluronic Acid for Treatment of Osteoarthritis in the Elderly
Current Pharmaceutical Design Influence of Lifestyle Measures on Hypertriglyceridaemia
Current Drug Targets Vasopressin and Oxytocin in Control of the Cardiovascular System
Current Neuropharmacology A Glance on the Role of Bacterial Siderophore from the Perspectives of Medical and Biotechnological Approaches
Current Drug Targets Biological Activities of Yarrow Species (Achillea spp.)
Current Pharmaceutical Design Drug Repurposing Approaches: Existing Leads for Novel Threats and Drug Targets
Current Protein & Peptide Science Anticancer Properties of Asian Water Monitor Lizard (Varanus salvator), Python (Malayopython reticulatus) and Tortoise (Cuora kamaroma amboinensis)
Anti-Cancer Agents in Medicinal Chemistry Translational Pharmacology in Aging Men with Benign Prostatic Hyperplasia: Molecular and Clinical Approaches to Alpha1-Adrenoceptors
Current Aging Science Inherited Renal Diseases
Current Pediatric Reviews Targeting Matrix Metalloproteinases in Acute Inflammatory Shock Syndromes
Combinatorial Chemistry & High Throughput Screening The Role of Cytokines in Sleep Regulation
Current Pharmaceutical Design